京都大学 ウイルス・再生医科学研究所 分子遺伝分野

業績


2018年
Antiviral Activity of Phenolic Derivatives in Pyroligneous Acid
from Hardwood, Softwood, and Bamboo
Li R,Narita R,Nishimura H, Marumoto S, Yamamoto SP,Ouda R, Yatagai M,Fujita T, Watanabe T.
ACS Sustainable Chem. Eng. 2018, 6(1), pp 119-126. doi: 10.1021/acssuschemeng.7b01265. Epub 2017 Oct 27.
(Li R, and Narita R contributed equally)

2017年
A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like
Event in Immunity against Respiratory Viruses.
Kasumba DM,Hajake T,Oh SW, Kotenko SV,Kato H,Fujita T.
J Immunol. 2017 Oct 1;199(7):2460-2474. doi: 10.4049/jimmunol.1700523. Epub 2017 Aug 28.

RIG-I-Like Receptors and Type I Interferonopathies.
Kato H,Oh SW,Fujita T.
J Interferon Cytokine Res. 2017 May;37(5):207-213. doi: 10.1089/jir.2016.0095.

Establishment of a human hepatocellular cell line capable of maintaining
long-term  replication of hepatitis B virus.
Yao WL,Ikeda S,Tsukamoto Y, Shindo K,Otakaki Y,Qin M,Iwasawa Y,Takeuchi F,Kaname Y, Chou YC, Chang C, WatashiK,Wakita T, Noda T,Kato H,Fujita T.
Int Immunol. 2017 Mar 1;29(3):109-120. doi: 10.1093/intimm/dxx012.

2016年
Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation
Enhances Susceptibility to Influenza Infection in Chronic Obstructive
Pulmonary Disease Epithelium.
Hsu AC, Parsons K, Moheimani F, Knight DA, Hansbro PM,Fujita T, Wark PA.
Am J Respir Cell Mol Biol. 2016 Jul;55(1):117-27. doi: 10.1165/rcmb.2015-0306OC.

Leader-Containing Uncapped Viral Transcript Activates RIG-I in
Antiviral Stress Granules.
Oh SW, Onomoto K,Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, Yoneyama M,Kato H,Fujita T.
PLoS Pathog. 2016 Feb 10;12(2):e1005444. doi: 10.1371/journal.ppat.1005444. eCollection 2016 Feb. Erratum in: PLoS Pathog.2016 Apr;12(4):e1005563. PMID: 26862753  Free PMC Article Similar articles Select item 26530735

2015年
RIG-I-like receptors and autoimmune diseases.
Kato H, Fujita T.
Curr Opin Immunol. 2015 Dec;37:40-5. doi: 10.1016/j.coi.2015.10.002. Review.
PMID: 26530735  Similar articles

The ASK family kinases differentially mediate induction of type I interferonandapoptosis during the antiviral response.

Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M,Fujita T,Taniguchi T, KawaokaY,Ichijo H, Gotoh Y.
Sci Signal. 2015 Aug 4;8(388):ra78. doi: 10.1126/scisignal.aab1883.

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
Andersen LL, Mork N, Reinert LS, Kofod-Olsen E,Narita R, Jorgensen SE, Skipper KA, Honing K, Gad HH, Ostergaard L,Orntoft TF,Hornung V, Paludan SR, Mikkelsen JG,Fujita T, Christiansen M, Hartmann R, Mogensen TH.
J Exp Med. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27.

Influence of genes suppressing interferon effects in peripheral blood
mononuclear cells during triple antiviral therapy for chronic hepatitis C.
Iijima S, Matsuura K, Watanabe T, Onomoto K,Fujita T, Ito K, Iio E, Miyaki T, Fujiwara K, Shinkai N, Kusakabe A, EndoM, Nojiri S, Joh T, Tanaka Y.
PLoS One. 2015 Feb 23;10(2):e0118000. doi: 10.1371/journal.pone.0118000. eCollection 2015.

Viral RNA detection by RIG-I-like receptors.
Yoneyama M, Onomoto K, Jogi M, Akaboshi T,Fujita T.
Curr Opin Immunol. 2015 Feb;32:48-53. doi: 10.1016/j.coi.2014.12.012. Epub 2015 Jan 14.

2014年
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of ViralInfection.
Narita R, Takahasi K,Murakami E,Hirano E, Yamamoto SP, Yoneyama M,Kato H,Fujita T.
PLoS Pathog. 2014 Oct 23;10(10):e1004417. doi: 10.1371/journal.ppat.1004417. eCollection 2014 Oct.

Autoimmunity caused by constitutive activation of cytoplasmic viral RNA sensors.
Kato H,Fujita T.
Cytokine Growth Factor Rev. 2014 Aug 19. pii: S1359-6101(14)00086-0. doi: 10.1016/j.cytogfr.2014.08.003. [Epub ahead of print]

Antiviral innate immunity and stress granule responses.
Onomoto K, Yoneyama M, Fung G,Kato H,Fujita T.
Trends Immunol. 2014 Sep;35(9):420-8. doi: 10.1016/j.it.2014.07.006. Epub 2014 Aug 19.

Aicardi-Goutieres syndrome is caused by IFIH1 mutations.
Oda H, Nakagawa K, Abe J, Awaya T,Funabiki M, Hijikata A, Nishikomori R, Funatsuka M, Ohshima Y, Sugawara Y,YasumiT,Kato H, ShiraiT,Ohara O,Fujita T, Heike T.
Am J Hum Genet. 2014 Jul 3;95(1):121-5. doi: 10.1016/j.ajhg.2014.06.007.

Sensing viral invasion by RIG-I like receptors.
Yoo JS,Kato H,Fujita T.
Curr Opin Microbiol. 2014 Aug;20:131-8. doi: 10.1016/j.mib.2014.05.011. Epub 2014 Jun 23.

DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviralstressgranule formation.
Yoo JS,Takahasi K,Ng CS,Ouda R, Onomoto K, Yoneyama M, Lai JC, Lattmann S, Nagamine Y, Matsui T, Iwabuchi K,KatoH,Fujita T
PLoS Pathog. 10(3) (2014)

Critical role of interferon-α constitutively produced in human hepatocytesinresponse to RNA virus infection.
Tsugawa Y,Kato H,Fujita T, Shimotohno K, Hijikata M.
PLoS One. 2014 Feb 26;9(2):e89869. doi: 10.1371/journal.pone.0089869. eCollection 2014 Mar.

Autoimmune disorders associated with gain of function of the intracellularsensorMDA5.
Funabiki M,Kato H, Miyachi Y, Toki H, Motegi H, Inoue M, Minowa O, Yoshida A, Deguchi K, Sato H, Ito S, Shiroishi T,Takeyasu K, Noda T,Fujita T
Immunity. 40(2):199-212 (2014)
(Funabiki M, and Kato H, contributed equally)

2013年
Virus-induced expression of retinoic acid inducible gene-I andmelanomadifferentiation-associated gene 5 in the cochlear sensory epithelium.
Hayashi Y, Onomoto K,Narita R, Yoneyama M,Kato H, Nakagawa T, Ito J, Taura A,Fujita T
Microbes and Infection. 15, 592-598 (2013)

Production of a Dominant-Negative Fragment Due to G3BP1 CleavageContributesto the Disruption of Mitochondria-Associated Protective Stress GranulesduringCVB3 Infection.
Fung G,Ng CS, Zhang J, Shi J, Wong J, Piesik P, Han L, Chu F, Jagdeo J, Jan E,Fujita T, Luo H
PLoS ONE 8(11): e79546. doi:10.1371/journal.pone.0079546 (2013)

EMCV Disrupts Stress Granules, the Critical Platform for TriggeringAntiviralInnate Immune Responses.
Ng CS,Jogi M,Yoo JS,Onomoto K,Koike S,Iwasaki T,Yoneyama M,Kato H,Fujita T.
J. Virol (2013) Epub

Functional characterization of domains of IPS-1 using an inducibleoligomerizationsystem.
Takamatsu S,Onoguchi K,Onomoto K,Narita R,Takahasi K,Ishidate F,Fujiwara TK,Yoneyama M,Kato H,Fujita T.
PLoS One. 8, (2013) Epub

2012年
Recognition of viruses in the cytoplasm by RLRs and other helicases-
-how conformational changes, mitochondrial dynamics and ubiquitination
control innate immune responses.
Ng CS,Kato H,Fujita T.
Int Immunol. 2012 Dec;24(12):739-49. doi: 10.1093/intimm/dxs099. Epub 2012 Oct 19.

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR inViralDetection and Innate Immunity.
Onomoto K,Jogi M,Yoo JS,Narita R,Morimoto S,Takemura A, Sambhara S,Kawaguchi A,Osari S,Nagata K,Matsumiya T,Namiki H,YoneyamaM,Fujita T.
PLoS One. 7, (2012) Epub

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity.
Nitta S,Sakamoto N,Nakagawa M,Kakinuma S,Mishima K,Kusano-Kitazume A,Kiyohashi K,Murakawa M,Nishimura-SakuraiY,Azuma S,Tasaka-Fujita M,Asahina Y,Yoneyama M,Fujita T,Watanabe M.
Hepatology. (2012) Epub

Identification of a Germicidal Compound against Picornavirus inBambooPyroligneous Acid.
Marumoto S,Yamamoto SP,Nishimura H,Onomoto K,Yatagai M,Yazaki K,Fujita T,Watanabe T.
J Agric Food Chem. (2012) Epub

Anti-CADM-140/MDA5 autoantibody titer correlates with disease activityandpredicts disease outcome in patients with dermatomyositis and rapidlyprogressiveinterstitial lung disease.
Sato S,Kuwana M,Fujita T,Suzuki Y.
Mod Rheumatol. (2012) Epub

The 3' untranslated regions of influenza genomic sequences are 5'PPP-independentligands for RIG-I.
Davis WG,Bowzard JB,Sharma SD,Wiens ME,Ranjan P,Gangappa S,Stuchlik O,Pohl J,Donis RO,Katz JM,Cameron CE,Fujita T,Sambhara S
PLoS One. 7, (2012) Epub

Amyopathic dermatomyositis developing rapidly progressive interstitial lungdiseasewith elevation of anti-CADM-140/MDA5 autoantibodies.
Sato S,Kuwana M,Fujita T,Suzuki Y.
Mod Rheumatol. 625 (2012) Epub

2011年
RIG-I-like receptors: cytoplasmic sensors for non-self RNA
Kato H,Takahasi K,Fujita T.
Immunol  Rev 243, 91-98, (2011)

55 Amino acid linker between helicase and carboxyl terminal domains of RIG-Ifunctions as a critical repression domain and determines inter-domain conformation.
Kageyama M,Takahasi K,Narita R,Hirai R,Yoneyama M,Kato H,Fujita T.
Biochem Biophys Res Commun 415, 75-81, (2011)

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Kleinman ME,Kaneko H,Cho WG,Dridi S,Fowler BJ,Blandford AD,Albuquerque RJ,Hirano Y,Terasaki H, Kondo M,Fujita T,Ambati BK,Tarallo V,Gelfand BD,Bogdanovich S,Baffi JZ,Ambati J.
Mol Ther. 101, (2012)

The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.
Biswas N,Liu S,Ronni T,Aussenberg SE,Liu W,Fujita T,Wang T.
PLoS One. 6, (2011) Epub

Dysregulation of IFN system can lead to poor response to pegylated interferonandribavirin therapy in chronic hepatitis C.
Onomoto K,Morimoto S,Kawaguchi T,Toyoda H,Tanaka M,Kuroda M,Uno K,Kumada T,Matsuda F,Shimotohno K,Fujita T,Murakami Y.
PLoS One. 6, (2011) Epub

Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections byMinorGroup Rhino viruses through Down-regulation of the Very Low DensityLipoprote inReceptor.
Ouda R,Onomoto K,Takahasi K,Edwards MR,Kato H,Yoneyama M,Fujita T.
J Biol Chem. 286, 26210-26219, (2011)

PAMPer and tRIGer: ligand-induced activation of RIG-I.
Bowzard JB,Davis WG,Jeisy-Scott V,Ranjan P,Gangappa S,Fujita T,Sambhara S.
Trends Biochem Sci. 314, (2011)

2010年
Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1.
Onoguchi K,Onomoto K,Takamatsu S,Jogi M,Takemura A,Morimoto S,Julkunen I,Namiki H,Yoneyama M,Fujita T.
PLoS Pathg. 6, e1001012, (2010)

Ser386 phosphorylation of transcription factor IRF-3 induces dimerizationandassociation with CBP/p300 without overall conformational change.
Takahasi K,Horiuchi M,Fujii K, Nakamura S, Noda NN,Yoneyama M,Fujita T,Inagaki F.
Genes Cells. 15, 901-910,(2010)

2009年
Identification of loss of function mutations in human genes encoding RIG-Iandmda5:Implications for resistance to type I diabetes.
Shigemoto T,Kageyama M,Hirai R,Zheng J,Yoneyama M,Fujita T.
J Biol Chem. 284,13348-13354,(2009)

Solution Structures of MDA5 and LGP2 C-terminal Domains:Identification oftheRNA Recognition Loop in RIG-I Like Receptors.
Takahasi K,Kumeta H, Tsuduki N,Narita R,Shigemoto T,Hirai R,Yoneyama M, Horiuchi M, Ogura K,Fujita T,Inagaki F.
J Biol Chem. 284,17465-17474,(2009)

RNA helicase encoded by melanoma differentiation-associated gene 5 is amajorautoantigenin patients with clinically amyopathic dermatomyositis:Associationwithrapidly progressive interstitial lung disease.
Sato S, Hoshino K, Satoh T,Fujita T,Kawakami Y,Fujita T, Kuwana M.
Arthritis Rheum., 60, 2193-2200, (2009)

RIG-I activation inhibits ebolavirus replication.
Spiropoulou CF, Ranjan P, Pearce MB, Sealy TK, Albarino CG, Gangappa S,Fujita T,Rollin PE, Nichol ST, Ksiazek TG,Sambhara S.
Virology. 392, 11-15, (2009)

2008年
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenacher K, Kirchhofer A, Brzozka K, Lammens A, Lammens K,Fujita T,Conzelmann KK, Krug A, Hopfner KP.
Mol.Cell. 29, 169-179, (2008)

Nonself RNA-sensing mechanism of RIG-I helicase and activation ofantiviralimmune responses.
Takahasi K,Yoneyama M,Nishihori T,Hirai R,Kumeta H,Narita R,Gale M Jr, Inagaki F,Fujita T.
Mol.Cell. 29, 428-440, (2008)

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-induciblegene-I and melanoma differentiation-associated gene 5.
Kato H,Takeuchi O, Mikamo-Satoh E,Hirai R,Kawai T, Matsushita K,Hiiragi A,Dermody TS,Fujita T,Akira S.
J. Exp. Med. 205, 1601-1610, (2008)

2007年
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
Arimoto K, Takahashi H, Hishiki T, Konishi H,Fujita T,Shimotohno K.
Proc. Natl. Acad. Sci. USA. 104, 7500-7505, (2007)

Regulation of innate antiviral defenses through a shared repressor domain in RIG-Iand LGP2.
Saito T,Hirai R,Loo YM, Owen D, Johnson CL, Sinha SC, Akira S,Fujita T,and Gale M Jr.
Proc. Natl. Acad. Sci. USA. 104, 582-587, (2007)

Viral infections activate types I and III interferon genes through acommonmechanism.
Onoguchi K,Yoneyama M,Takemura A,Akira S, Taniguchi T, Namiki H,Fujita T.
J Biol Chem. 282, 7576-7581, (2007)

Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependentantiviral responses in human lung epithelial cells.
Le Goffic R, Pothlichet J, Vitour D,Fujita T,Meurs E, Chignard M, Si-Tahar M.
J Immunol. 178, 3368-3372, (2007)

NS1 protein of influenza A virus inhibits the function of intracytoplasmicpathogensensor, RIG-I.
Guo Z, Chen LM, Zeng H, Gomez JA, Plowden J,Fujita T,Katz JM, Donis RO, Sambhara S.
Am J Respir Cell Mol Biol. 36, 263-269, (2007)

Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response.
Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itsui Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH,Yoneyama M,Fujita T,Wakita T,Maekawa S, Enomoto N, Watanabe M.
J Gen Virol. 88, 3323-3333, (2007)

2006年
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitisCvirus infection.
Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T., Ishida H.,Yoneyama M.,Fujita T.,SaitoT.,Lee WM,Hagedorn CH, Lau DT, Weinman SA, Lemon SM, and Gale M Jr.
Proc. Natl. Acad. Sci. USA. 103, 6001-6006, (2006)

Role of the alpha/beta interferon response in the acquisition of susceptibilitytopoliovirus by kidney cells in culture.
Yoshikawa T, Iwasaki T, Ida-Hosonuma M,Yoneyama M,Fujita T,Horie H, Miyazawa M, Abe S, Simizu B, and Koike S.
J Virol. 80, 4313-4325, (2006)

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Kato H,Takeuchi O, Sato S,Yoneyama M,Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O,OtsuK,Tsujimura T,Koh CS, Reis e Sousa C, Matsuura Y,Fujita T,and Akira S.
Nature. 441, 101-105, (2006)a

A structural basis for discriminating between self and nonself double-strandedRNAs in mammalian cells.
Marques JT, Devosse T, Wang D, Zamanian-Daryoush M, Serbinowski P, Hartmann R,Fujita T,Behlke MA, Williams BR.
Nat Biotechnol. 24, 559-565, (2006)

NAK-associated protein 1 participates in both the TLR3 and thecytoplasmicpathways in typeI IFN induction.
Sasai M, Shingai M, Funami K,Yoneyama M,Fujita T,Matsumoto M, Seya T.
J Immunol. 177, 8676-8683, (2006)

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