Institute for Frontier Life and Medical Sciences, Kyoto University

Requirement of TCR signal for γδ T cell homeostasis in peripheral organs

Shizue Tani-ichi1,2, Keisuke Wagatsuma1, Takahiro Hara1, Guangwei Cui1, Shinya Abe1, Hitoshi Miyachi3, Satsuki Kitano3, and Koichi Ikuta1

(1Laboratory of Immune Regulation, Institute for Frontier Life and Medical Sciences, Kyoto University; 2Laboratory of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University; 3Reproductive Engineering Team, Institute for Frontier Life and Medical Sciences, Kyoto University)

“Innate-like CD27+CD45RBhigh γδ T cells require TCR signaling for homeostasis in peripheral lymphoid organs”

Journal of Immunology (2020) 204: 2671-2684. doi: 10.4049/jimmunol.1801243

Abstract

IL-7 and TCR signals are required for homeostasis of naive αβ T cells. It is already known that γδ T cells require IL-15 and IL-7 for their homeostasis. However, it remains unknown whether TCR signal is necessary for γδ T cell homeostasis in the periphery. In this study, we generated mice lacking an enhancer of the TCRγ locus to attenuate γδTCR signaling. Maintenance of a subset of IFN-γ-producing γδ T cells was impaired in the secondary lymphoid organs of the TCRγ enhancer deletion mice. Thus, this study suggests the possibility that γδ T cells require TCR signaling for their homeostasis.

 

Figure Homeostasis of a subset of γδ T cells in the periphery is impaired in TCRγ enhancer deletion mice