DEPARTMENT OF VIRUS RESEARCHLAB. OF MEDICAL VIROLOGY
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Professor
Takao Hashiguchi |
MESSAGE FROM THE LAB
MEMBER
| Professor |  Takao Hashiguchi |
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| Assistant Professor |
Tateki Suzuki |
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| Assistant Professor |
Yuma sato |
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| Assistant Professor |
Kanako Kimura |
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| Staff | Secretary: Yoko Enjo Graduate Students: Jie Sasaki (D1), Hisano Yajima (M1) Technical Assistant: Yukari Nakajima |
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RESEARCH
Elucidation of viral pathogenesis and development of prevention and therapeutics for viral infections
Infectious diseases still have been a fatal threat to children, worldwide. To solve the problem, we have been studying on pediatric virology. In particular, we focus on the mechanisms of viral entry into cells and the inhibition of entry by compounds, peptides, glycans, and antibodies, using a combination of virological and structural biological approaches. Our major goals are the elucidation of viral pathogenesis and the development of preventive and therapeutic methods for viral diseases.
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Our laboratory focuses on pediatric viral diseases. Combining molecular biology, biochemistry, physical chemistry, virology, and structural biology techniques, we have been studying the mechanisms by which viral infections cause pathogenesis and the mechanisms by which the human immune system counteracts viral infections. As for structural analysis, we mainly utilize X-ray crystallography and cryo-electron microscopy to visualize the interactions between host factors/therapeutic molecules and viral proteins. |
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Building on the above results, we also have been studying basic research for vaccine development based on protein structures, and developing therapeutic antibodies, compounds, and peptides. In particular, we have been focusing on designing vaccine antigens and developing novel methods for antibody production. |
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