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DEPARTMENT OF VIRUS RESEARCHLAB. OF ULTRASTRUCTURAL VIROLOGY

Professor Takeshi Noda Professor

Takeshi Noda

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MESSAGE FROM THE LAB

You can do it! The heart is what drives us! This is a line of Kamado Tanjiro in Demon Slayer, which is one of my favorite comics. In 2019, the world has been changed by the emergence of a virus. However, we, virus researchers, are the ones who can change that world again. No one knows what virus will cause the next pandemic, but I believe that our enthusiastic studies will help change the future for the better.

MEMBER

Professor
Takeshi Noda		 WebsiteMail
Associate
Professor
Yukihiko Sugita		 WebsiteMail
Assistant
Professor
Masahiro Nakano		 Mail
Assistant
Professor
Yukiko Muramoto		 Mail

RESEARCH

Exploring the virus replication mechanism

Our laboratory has been investigating the replication mechanisms of influenza virus, Ebola viruses, and SARS-CoV-2. One of the most unique features of our research is imaging and structural analysis, by combining conventional virological techniques with various microscopic methods such as cryo-electron microscopy and high-speed atomic force microscopy. We also investigate virus replication and host responses against virus infection using human ES- and iPS-derived organoids, which mimic virus infection in the human body. Our unique approaches will provide important insights into virus replication mechanisms and advance our understanding of the molecular and structural basis of the replication mechanism.

Genome packaging mechanism of influenza viruses

A 3D model of an influenza virus particle reconstructed by electron tomography. Eight RNPs arranged in a specific pattern are packaged in the virion. (Left) transverse section (Right) longitudinal section

Structure of Ebola virus NP-RNA complex

Structure of Ebola virus nucleoprotein-RNA complex determined by using single particle cryo-electron microscopy. (Left) Helical NP-RNA complex (Right) An atomic model of an NP-RNA protomer (Sugita et al., Nature, 2018)