MESSAGE FROM THE LAB
Exploring the virus replication mechanism
Our laboratory has been investigating the replication mechanisms of influenza virus, Ebola viruses, and SARS-CoV-2. One of the most unique features of our research is imaging and structural analysis, by combining conventional virological techniques with various microscopic methods such as cryo-electron microscopy and high-speed atomic force microscopy. We also investigate virus replication and host responses against virus infection using human ES- and iPS-derived organoids, which mimic virus infection in the human body. Our unique approaches will provide important insights into virus replication mechanisms and advance our understanding of the molecular and structural basis of the replication mechanism.
Genome packaging mechanism of influenza viruses
A 3D model of an influenza virus particle reconstructed by electron tomography. Eight RNPs arranged in a specific pattern are packaged in the virion. (Left) transverse section (Right) longitudinal section
Structure of Ebola virus NP-RNA complex
Structure of Ebola virus nucleoprotein-RNA complex determined by using single particle cryo-electron microscopy. (Left) Helical NP-RNA complex (Right) An atomic model of an NP-RNA protomer (Sugita et al., Nature, 2018)