DEPARTMENT OF Biosystems ScienceLAB. OF RNA system
MESSAGE FROM THE LAB
RESEARCH
RNA biology
RRNA and RNA-binding proteins form ribonucleoprotein complexes (RNPs). We are studying a wide range of biological phenomena related to the life cycle of RNPs, including their formation (birth), functional expression (daily life), and disassembly (death). Our main topics are (1) RNA processing and transport, (2) regulation of RNA expression by viruses, (3) quality control of ribosomal particles, and (4) sorting of RNA polymerase II transcripts. We are also supporting a team of Kyoto University students participating in the International Genetically Engineered Machine competition (iGEM).
Life cycle of RNA/RNPA variety of important biological themes exists behind the life cycle of RNA/RNP. For example, RNA binds to specific proteins to form functional RNPs. When RNPs lose their function due to errors during synthesis or stress, quality control mechanisms detect and eliminate such molecules. We elucidate these mechanisms using the tools of molecular biology and biochemistry. |