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DEPARTMENT OF Biosystems ScienceLAB. OF RNA system

MESSAGE FROM THE LAB

RNA is an old and new molecule.
Like DNA, RNA can store information as nucleotide sequences. But that is not the only function of RNA. For example, it is known to function as a scaffold for assembly of many proteins into specific structures, or as a catalyst for reactions to proceed. These properties have led to the theory that the first life on earth consisted of RNA genes and RNA catalysts (the RNA world hypothesis).
Despite its ancient origins and the fact that it has been the subject of research by many scientists, there is still much that remains unknown about RNA. In recent years, there has been a lot of research not only to understand the relationship between RNA and biological phenomena, but also to utilize RNA for medical and other applications. We hope to explore the mysteries of RNA using molecular biology and biochemistry, and to open up new areas of research.
Anyone is welcomed anytime to see our laboratory.

RESEARCH

RNA biology

RRNA and RNA-binding proteins form ribonucleoprotein complexes (RNPs). We are studying a wide range of biological phenomena related to the life cycle of RNPs, including their formation (birth), functional expression (daily life), and disassembly (death). Our main topics are (1) RNA processing and transport, (2) regulation of RNA expression by viruses, (3) quality control of ribosomal particles, and (4) sorting of RNA polymerase II transcripts. We are also supporting a team of Kyoto University students participating in the International Genetically Engineered Machine competition (iGEM).

Life cycle of RNA/RNP

A variety of important biological themes exists behind the life cycle of RNA/RNP. For example, RNA binds to specific proteins to form functional RNPs. When RNPs lose their function due to errors during synthesis or stress, quality control mechanisms detect and eliminate such molecules. We elucidate these mechanisms using the tools of molecular biology and biochemistry.