{"id":6088,"date":"2025-03-26T14:02:25","date_gmt":"2025-03-26T05:02:25","guid":{"rendered":"https:\/\/www.infront.kyoto-u.ac.jp\/?page_id=6088"},"modified":"2026-04-17T08:58:49","modified_gmt":"2026-04-16T23:58:49","slug":"labo32","status":"publish","type":"page","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/laboratory\/labo32\/","title":{"rendered":"LAB. OF Tissue Homeostasis"},"content":{"rendered":"<div id=\"pagehead\">\n<h2>LABORATORY<span>About our laboratory<\/span><\/h2>\n<\/div>\n<div id=\"pankuzu\"><a href=\"..\/..\/\">HOME<\/a> &gt; <a href=\"..\/\">Faculty<\/a> &gt; LAB. OF Biological Data Science<\/div>\n<p><main id=\"main\" class=\"laboratory\"><\/p>\n<div class=\"contents no-photo\">\n<div class=\"department\">\n<p class=\"field\"><span>DEPARTMENT OF Biosystems Science<\/span>LAB. OF Biological Data Science<\/p>\n<\/p><\/div>\n<ul class=\"web-list\" style=\"padding-bottom:150px;\">\n<li><!--<a href=\"https:\/\/www2.infront.kyoto-u.ac.jp\/Toyoshima-HP\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_web.svg\" alt=\"Website\"><\/a>--><\/li>\n<\/ul>\n<div class=\"message\">\n<h3 class=\"tit\">MESSAGE FROM THE LAB<\/h3>\n<p>Our body changes its form and function depending on the life stage and lifestyle to maintain homeostasis. During pregnancy, various maternal organs such as the brain, liver, thymus, mammary gland, and skin are reorganized to accommodate fetus growth. In aging and obesity, tissue degeneration along with chronic inflammation is induced. In our laboratory, we aim to elucidate the mechanism of organ remodeling that accompanies physiological changes in the body, and to understand the mechanism that maintains the homeostasis of the body throughout the life stage. We are also aiming to develop new regenerative medical technologies and therapeutic agents based on the mechanism of physiological organ remodeling.<br \/>\nFor information on bioinformatics technology development, please see the link of Associate Professor Alexis Vandenbon.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"member\">\n<div class=\"contents\">\n<div class=\"assistant\">\n<div>\n<p><span class=\"position\">Associate Professor<\/span><br \/><span class=\"name\">Alexis Vandenbon<\/span><\/p>\n<p><a href=\"https:\/\/genomics.virus.kyoto-u.ac.jp\/alexisvdb\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_web.svg\" alt=\"Website\"><\/a><a href=\"m&#97;&#105;&#108;&#116;&#111;&#58;&#97;&#108;&#101;&#120;&#105;&#115;&#118;&#100;&#98;&#64;&#105;&#110;&#102;&#114;&#111;&#110;&#116;&#46;&#107;&#121;&#111;&#116;&#111;&#45;&#117;&#46;&#97;&#99;&#46;jp\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_ms.svg\" alt=\"Mail\"><\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"research\">\n<h3 class=\"tit\">RESEARCH<\/h3>\n<div class=\"contents\">\n<div class=\"field\">\n<h4><span>Tissue remodeling in physiological changes and medical application<\/span><\/h4>\n<p>Our laboratory is studying the physiological organ remodeling during pregnancy, obesity, and aging. We aim to clarify the mechanism by which heterologous cell networks such as blood vessels \/ nerves \/ immune \/ stromal \/ epithelial cells reorganize tissues and organs in cooperation with mechanofields and humoral factors in tissues. Based on the mechanism of the physiological organ remodeling, we are developing new medical technologies and therapeutic agents that contribute to damaged tissue repair and anti-aging. We are also investigating the interface between maternal organ remodeling and fetal development.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"bg-field\">\n<div class=\"field\">\n<h4>Maternal organ remodeling during pregnancy<\/h4>\n<div class=\"with-photo\">\n<p class=\"txt\">Elucidation of the mechanism of maternal organ remodeling during pregnancy by using combining methods such as genetically modified mice, single-cell gene expression analysis, in vivo imaging, and mechanical analysis. In particular, we are focusing on the maternal skin and liver, which rapidly expand during pregnancy, and the crosstalk between maternal organ remodeling and fetal growth.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_toyoshima_img.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"field\">\n<h4>Tissue deterioration in aging and obesity<\/h4>\n<div class=\"with-photo\">\n<p class=\"txt\">Studying the degenerative mechanism of skin in aging and obesity from the viewpoint of tissue stem cells, mechanobiology, and chronic inflammation. We aim to develop anti-aging technology that controls the stem cells and microenvironment that surround them.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_toyoshima_img2.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"field\">\n<h4>Development of treatments and drugs for tissue repair and regeneration <\/h4>\n<div class=\"with-photo\">\n<p class=\"txt\">Based on the mechanism of the physiological organ remodeling in pregnancy, aging, and obesity, we are conducting research on compounds, bioactive peptides, and cell therapies that promote damaged tissue repair. We are also developing gene targeting technology for gene therapy.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_toyoshima_img3.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>  \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<br \/>\n<\/main><\/p>\n","protected":false},"excerpt":{"rendered":"<p>LABORATORYAbout our laboratory HOME &gt; Faculty &gt; LAB. OF Biological Data Science DEPARTMENT OF Biosystems ScienceLAB. OF Biological Data Science MESSAGE FROM THE LAB Our body changes its form and function depending on the life stage and lifestyle to maintain homeostasis. During pregnancy, various maternal organs such as the brain, liver, thymus, mammary gland, and [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":131,"menu_order":32,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/www.infront.kyoto-u.ac.jp\/?page_id=6086","footnotes":""},"class_list":["post-6088","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=6088"}],"version-history":[{"count":5,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6088\/revisions"}],"predecessor-version":[{"id":7514,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6088\/revisions\/7514"}],"up":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/131"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=6088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}