{"id":6112,"date":"2025-03-26T14:22:38","date_gmt":"2025-03-26T05:22:38","guid":{"rendered":"https:\/\/www.infront.kyoto-u.ac.jp\/?page_id=6112"},"modified":"2026-04-10T14:49:14","modified_gmt":"2026-04-10T05:49:14","slug":"labo48","status":"publish","type":"page","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/laboratory\/labo48\/","title":{"rendered":"Lab. of aging and infection control"},"content":{"rendered":"<div id=\"pagehead\">\n<h2>LABORATORY<span>About our laboratory<\/span><\/h2>\n<\/div>\n<div id=\"pankuzu\"><a href=\"..\/..\/\">HOME<\/a> &gt; <a href=\"..\/\">Faculty<\/a> &gt; Lab. of aging and infection control<\/div>\n<p><main id=\"main\" class=\"laboratory\"><\/p>\n<div class=\"contents\">\n<div class=\"department\">\n<p class=\"field\"><span>DEPARTMENT OF Biosystems Science<\/span>Lab. of aging and infection control<\/p>\n<\/p><\/div>\n<ul class=\"web-list\">\n<li><a href=\"https:\/\/www.kagenakadailab.com\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_web.svg\" alt=\"Website\"><\/a><\/li>\n<\/ul><\/div>\n<div class=\"message\">\n<h3 class=\"tit\">MESSAGE FROM THE LAB<\/h3>\n<div class=\"contents\">\n<p>Using C. elegans and mice as model organisms, we are studying the mechanisms of aging and infection and how to control them. In recent years, it has become clear that inflammation is closely related not only to infection but also to various chronic diseases, and we are focusing on the possibility of using intestinal bacteria to regulate inflammation. We invite you to join our research.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"photo\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/labo48\/photo2025.jpg\" alt=\"Lab. of aging and infection control\"><\/div>\n<div class=\"member\">\n<div class=\"contents\">\n<div class=\"professer\">\n<div class=\"photo-p\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/labo48\/prof.jpg\" alt=\"Eriko Kage-Nakadai\"><\/div>\n<div class=\"identity\">\n<p><span class=\"position\">Professor<\/span><span class=\"name\">Eriko Kage-Nakadai<\/span><\/p>\n<\/div>\n<ul class=\"msg-list\">\n<li><a href=\"https:\/\/www.kagenakadailab.com\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_web.svg\" alt=\"Website\"><\/a><\/li>\n<li><a href=\"m&#97;i&#108;&#116;&#111;&#58;&#110;&#97;&#107;&#97;&#100;&#97;i&#64;i&#110;&#102;&#114;&#111;&#110;&#116;&#46;&#107;&#121;&#111;&#116;&#111;&#45;&#117;&#46;&#97;&#99;&#46;jp\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_ms.svg\" alt=\"Mail\"><\/a><\/li>\n<\/ul><\/div>\n<div class=\"assistant\">\n<div>\n<p><span class=\"position\">Assistant Professor<\/span><br \/><span class=\"name\">Yoshihiko Tanimoto<\/span><\/p>\n<p><a href=\"https:\/\/sites.google.com\/view\/ytani\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_web.svg\" alt=\"Website\"><\/a><a href=\"m&#97;&#105;&#108;&#116;&#111;&#58;&#121;&#45;&#116;&#97;n&#105;m&#111;&#116;&#111;&#64;&#105;n&#102;&#114;&#111;n&#116;&#46;&#107;&#121;&#111;&#116;&#111;&#45;&#117;&#46;&#97;&#99;&#46;jp\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_ms.svg\" alt=\"Mail\"><\/a><\/p>\n<\/p><\/div>\n<div>\n<p><span class=\"position\">Assistant Professor<\/span><br \/><span class=\"name\">Misaki Okahata<\/span><\/p>\n<p><a href=\"m&#97;&#105;&#108;&#116;o&#58;o&#107;&#97;&#104;&#97;&#116;&#97;&#64;&#105;&#110;&#102;&#114;o&#110;&#116;&#46;&#107;&#121;o&#116;o&#45;&#117;&#46;&#97;&#99;&#46;jp\"><img decoding=\"async\" src=\"\/assets\/img\/laboratory\/i_ms.svg\" alt=\"Mail\"><\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"research\">\n<h3 class=\"tit\">RESEARCH<\/h3>\n<div class=\"contents\">\n<div class=\"field\">\n<h4><span>Comprehension and control of aging, infection and microbiota<\/span><\/h4>\n<p>Microbiota indigenous to the gut and skin are deeply involved in aging, infection, and inflammation of the host. We will try to elucidate the mechanisms and establish control methods of aging, infection and inflammation in order to contribute to human health, using model organisms.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"bg-field\">\n<div class=\"field\">\n<div class=\"with-photo\">\n<p class=\"txt\">Using C. elegans and mice, we have elucidated the mechanisms of the host-microbiota interactions. Bacteria are interestingly heterogeneous even in the same species, and attractive as a tool that could control aging and infection.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_nakadai_img1.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"field\">\n<div class=\"with-photo\">\n<p class=\"txt\">Prevention and alleviation of the pathophysiology of inflammatory bowel disease, which has been increasing in recent years, is one of the most important issues. Although E. coli is often highlighted for its diarrheagenic properties, we have found that there is a group of E. coli strains that show inhibitory activity in the induction of inflammatory cytokines. We will also search for enterobacterial species and strains that inhibit inflammation.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_nakadai_img2.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"field\">\n<div class=\"with-photo\">\n<p class=\"txt\">Mitochondria are closely related to aging and are a possible target for the control of aging. We have identified pharmaceutical compounds that extend lifespan by activating the mitochondrial UPR through screening using C. elegans. C. elegans is one of the effective model organisms that can provide a simple and rapid approach to phenomena that cannot be evaluated at the cellular level such as lifespan.<\/p>\n<p class=\"img\"><img decoding=\"async\" src=\"\/images\/lab_nakadai_img3.jpg\" alt=\"\"><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>  \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<br \/>\n<\/main><\/p>\n","protected":false},"excerpt":{"rendered":"<p>LABORATORYAbout our laboratory HOME &gt; Faculty &gt; Lab. of aging and infection control DEPARTMENT OF Biosystems ScienceLab. of aging and infection control MESSAGE FROM THE LAB Using C. elegans and mice as model organisms, we are studying the mechanisms of aging and infection and how to control them. In recent years, it has become clear [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":131,"menu_order":48,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/www.infront.kyoto-u.ac.jp\/?page_id=6110","footnotes":""},"class_list":["post-6112","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=6112"}],"version-history":[{"count":5,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6112\/revisions"}],"predecessor-version":[{"id":7477,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/6112\/revisions\/7477"}],"up":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/pages\/131"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=6112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}