{"id":1077,"date":"2021-05-10T06:17:08","date_gmt":"2021-05-10T06:17:08","guid":{"rendered":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1077"},"modified":"2022-06-22T16:14:56","modified_gmt":"2022-06-22T07:14:56","slug":"post-1074","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/post-1074\/","title":{"rendered":"A new mechanism of regulatory T cell generation to suppress excessive immune responses \u2015Non-coding DNA sequences indispensable for immune tolerance were discovered\u30fc"},"content":{"rendered":"<p>Ryoji Kawakami,<sup>1,3 <\/sup>Yohko Kitagawa,<sup>1,3<\/sup> Kelvin Y. Chen,<sup>3<\/sup> Masaya Arai,<sup>3<\/sup> Daiya Ohara,<sup>2<\/sup> Yamami Nakamura,<sup>3<\/sup> Keiko Yasuda,<sup>1,3<\/sup> Motonao Osaki,<sup>1,3<\/sup> Norihisa Mikami,<sup>1,3<\/sup> Caleb A. Lareau,<sup>4<\/sup> Hitomi Watanabe,<sup>2<\/sup> Gen Kondoh,<sup>2<\/sup> Keiji Hirota,<sup>2<\/sup> Naganari Ohkura,<sup>3<\/sup> and Shimon Sakaguchi<sup>1,3<\/sup><\/p>\n<p>(1 Department of Experimental Pathology, Institute for Frontier Life and Medical Sciences, Kyoto University, 2 Laboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, 3 Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, 4 Departments of Genetics and Pathology, Stanford University)<\/p>\n<p><strong>Distinct Foxp3 enhancer elements coordinate development, maintenance and function of regulatory T cells<\/strong><\/p>\n<p><strong><em>Immunity <\/em><\/strong>(2021) doi.org\/10.1016\/j.immuni.2021.04.005<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ryoji Kawakami,1,3 Yohko Kitagawa,1,3 Kelvin Y. Chen,3 Masaya Arai,3 Daiya Ohara,2 Yamami Nakamura,3 Keiko Yasuda,1,3 Motonao Osaki,1,3 Norihisa Mikami,1,3 Caleb A. Lareau,4 Hitomi Watanabe,2 Gen Kondoh,2 Keiji Hirota,2 Naganari Ohkura,3 and Shimon Sakaguchi1,3 (1 Department of Experimental Pathology, Institute for Frontier Life and Medical Sciences, Kyoto University, 2 Laboratory of Integrative Biological Science, Institute for [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1079,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1074","footnotes":""},"categories":[1],"tags":[],"labo":[],"labo_en":[60],"class_list":["post-1077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo_en-labo19","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=1077"}],"version-history":[{"count":3,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1077\/revisions"}],"predecessor-version":[{"id":1081,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1077\/revisions\/1081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/1079"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=1077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=1077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=1077"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=1077"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=1077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}