{"id":1665,"date":"2020-07-07T04:12:04","date_gmt":"2020-07-07T04:12:04","guid":{"rendered":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1665"},"modified":"2022-06-22T16:49:29","modified_gmt":"2022-06-22T07:49:29","slug":"post-1661","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/post-1661\/","title":{"rendered":"Competition between STAT5 and phosphatidylinositol 3-kinase under IL-7 receptor signaling modulates T cell development and homeostasis"},"content":{"rendered":"<p>Guangwei Cui<sup>1<\/sup>, Akihiro Shimba<sup>1,2<\/sup>, Guangyong Ma<sup>3<\/sup>, Kazuhiko Takahara<sup>4<\/sup>, Shizue Tani-ichi<sup>1,2<\/sup>, Yuanbo Zhu<sup>1,2<\/sup>, Takuma Asahi<sup>1,2<\/sup>, Akifumi Abe<sup>1<\/sup>, Hitoshi Miyachi<sup>5<\/sup>, Satsuki Kitano<sup>5<\/sup>, Takahiro Hara<sup>1<\/sup>, Jun-ichirou Yasunaga<sup>3,6<\/sup>, Hirotsugu Suwanai<sup>7<\/sup>, Hisakata Yamada<sup>8<\/sup>, Masao Matsuoka<sup>3,6<\/sup>, Kohjiro Ueki<sup>9<\/sup>, Yasunobu Yoshikai<sup>8<\/sup>, and Koichi Ikuta<sup>1<\/sup><\/p>\n<p>(<sup>1<\/sup>Laboratory of Immune Regulation, Institute for Frontier Life and Medical Sciences, Kyoto University; <sup>2<\/sup>Graduate School of Medicine, Kyoto University; <sup>3<\/sup>Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University; <sup>4<\/sup>Graduate School of Biostudies, Kyoto University; <sup>5<\/sup>Reproductive Engineering Team, Institute for Frontier Life and Medical Sciences, Kyoto University; <sup>6<\/sup>Faculty of Life Sciences, Kumamoto University; <sup>7<\/sup>Tokyo Medical University Hospital; <sup>8<\/sup>Medical Institute of Bioregulation, Kyushu University; <sup>9<\/sup>National Center for Global Health and Medicine)<\/p>\n<p>\u201cIL-7R-dependent phosphatidylinositol 3-kinase competes with the STAT5 signal to modulate T cell development and homeostasis\u201d<\/p>\n<p><strong><em>Journal of Immunology <\/em><\/strong><strong>(2020)<\/strong> 204: 844-857. doi: <a href=\"https:\/\/doi.org\/10.4049\/jimmunol.1900456\">10.4049\/jimmunol.1900456<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Guangwei Cui1, Akihiro Shimba1,2, Guangyong Ma3, Kazuhiko Takahara4, Shizue Tani-ichi1,2, Yuanbo Zhu1,2, Takuma Asahi1,2, Akifumi Abe1, Hitoshi Miyachi5, Satsuki Kitano5, Takahiro Hara1, Jun-ichirou Yasunaga3,6, Hirotsugu Suwanai7, Hisakata Yamada8, Masao Matsuoka3,6, Kohjiro Ueki9, Yasunobu Yoshikai8, and Koichi Ikuta1 (1Laboratory of Immune Regulation, Institute for Frontier Life and Medical Sciences, Kyoto University; 2Graduate School of Medicine, Kyoto [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1663,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1661","footnotes":""},"categories":[1],"tags":[],"labo":[],"labo_en":[51],"class_list":["post-1665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo_en-labo07","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=1665"}],"version-history":[{"count":2,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1665\/revisions"}],"predecessor-version":[{"id":1667,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1665\/revisions\/1667"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/1663"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=1665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=1665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=1665"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=1665"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=1665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}