{"id":1736,"date":"2019-04-11T05:14:55","date_gmt":"2019-04-11T05:14:55","guid":{"rendered":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1736"},"modified":"2022-08-19T09:19:22","modified_gmt":"2022-08-19T00:19:22","slug":"post-1732","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/post-1732\/","title":{"rendered":"Comprehensive identification of cancer drug targets using CRISRP-Cas9 screens"},"content":{"rendered":"<p>Fiona M. Behan <sup>1,2<\/sup>\u3001Francesco Iorio <sup>1,2,3<\/sup>\u3001Gabriele Picco <sup>1<\/sup>\u3001Emanuel Gon\u00e7alves <sup>1<\/sup>\u3001Charlotte M. Beaver <sup>1<\/sup>\u3001Giorgia Migliardi <sup>4,5<\/sup>\u3001Rita Santos <sup>6<\/sup>\u3001Yanhua Rao <sup>7<\/sup>\u3001Francesco Sassi <sup>4<\/sup>\u3001Marika Pinnelli <sup>4,5<\/sup>\u3001Rizwan Ansari <sup>1<\/sup>\u3001Sarah Harper <sup>1<\/sup>\u3001David Adam Jackson <sup>1<\/sup>\u3001Rebecca McRae <sup>1<\/sup>\u3001Rachel Pooley <sup>1<\/sup>\u3001Piers Wilkinson <sup>1<\/sup>\u3001Dieudonne van der Meer <sup>1<\/sup>\u3001David Dow <sup>2,6<\/sup>\u3001Carolyn BuserDoepner <sup>2,7<\/sup>\u3001Andrea Bertotti <sup>4,5<\/sup>\u3001Livio Trusolino <sup>4,5<\/sup>\u3001Euan A. Stronach <sup>2,6<\/sup>\u3001Julio SaezRodriguez <sup>2,3,8,9,10<\/sup>\u3001 Kosuke Yusa <sup>1,2,11<\/sup>\u3001Mathew J. Garnett <sup>1,2<\/sup><\/p>\n<p>\uff081 Wellcome Sanger Institute, 2 Open Targets, 3 European Molecular Biology Laboratory, 4 Candiolo Cancer InstituteFPO, 5 Department of Oncology, University of Torino, 6 GlaxoSmithKline Research and Development, Stevenage, 7 GlaxoSmithKline Research and Development, Collegeville, 8 Faculty of Medicine, RWTH Aachen University, 9 Institute for Computational Biomedicine, Heidelberg University, 10 Heidelberg University Hospital, 11 Laboratory of Stem Cell Genetics, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University\uff09<\/p>\n<p>\u201d<strong>Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens<\/strong>\u201d<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1103-9\"><strong><em>Nature <\/em><\/strong>(2019) doi.org\/10.1038\/s41586-019-1103-9<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fiona M. Behan 1,2\u3001Francesco Iorio 1,2,3\u3001Gabriele Picco 1\u3001Emanuel Gon\u00e7alves 1\u3001Charlotte M. Beaver 1\u3001Giorgia Migliardi 4,5\u3001Rita Santos 6\u3001Yanhua Rao 7\u3001Francesco Sassi 4\u3001Marika Pinnelli 4,5\u3001Rizwan Ansari 1\u3001Sarah Harper 1\u3001David Adam Jackson 1\u3001Rebecca McRae 1\u3001Rachel Pooley 1\u3001Piers Wilkinson 1\u3001Dieudonne van der Meer 1\u3001David Dow 2,6\u3001Carolyn BuserDoepner 2,7\u3001Andrea Bertotti 4,5\u3001Livio Trusolino 4,5\u3001Euan A. Stronach 2,6\u3001Julio SaezRodriguez 2,3,8,9,10\u3001 Kosuke Yusa [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1734,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/lime.infront.kyoto-u.ac.jp\/?p=1732","footnotes":""},"categories":[1],"tags":[],"labo":[],"labo_en":[74],"class_list":["post-1736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo_en-labo40","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=1736"}],"version-history":[{"count":3,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1736\/revisions"}],"predecessor-version":[{"id":2948,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/1736\/revisions\/2948"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/1734"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=1736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=1736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=1736"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=1736"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=1736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}