{"id":6974,"date":"2025-11-06T15:36:14","date_gmt":"2025-11-06T06:36:14","guid":{"rendered":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=6974"},"modified":"2025-11-06T15:36:14","modified_gmt":"2025-11-06T06:36:14","slug":"post-6966","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/post-6966\/","title":{"rendered":"Analysis of Memory Abnormalities in an Alzheimer\u2019s Disease Mouse Model Using Computational Modeling"},"content":{"rendered":"<p><strong>Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer\u2019s disease<\/strong><\/p>\n<p><em>eLife<\/em> November 4, 2025.<br \/>\nhttps:\/\/doi.org\/10.7554\/eLife.105347.3<\/p>\n<p>Mei-Lun Huang<sup>1<\/sup>, Yusuke Suzuki*<sup>1,2,5<\/sup>, Hiroki Sasaguri<sup>3,4<\/sup>, Takaomi C Saido<sup>3<\/sup>, Itaru Imayoshi*<sup>1,2,5<\/sup><\/p>\n<p>1: Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan<br \/>\n2: Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan<br \/>\n3: Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan<br \/>\n4: Dementia Pathophysiology Collaboration Unit, RIKEN Center for Brain Science, Saitama, Japan<br \/>\n5: Laboratory of Deconstruction of Stem Cells, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan<\/p>\n<p>*Corresponding author<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer\u2019s disease eLife November 4, 2025. https:\/\/doi.org\/10.7554\/eLife.105347.3 Mei-Lun Huang1, Yusuke Suzuki*1,2,5, Hiroki Sasaguri3,4, Takaomi C Saido3, Itaru Imayoshi*1,2,5 1: Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan 2: Center for Living Systems Information Science, [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":6972,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=6966","footnotes":""},"categories":[1],"tags":[],"labo":[],"labo_en":[76],"class_list":["post-6974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo_en-labo43","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/6974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=6974"}],"version-history":[{"count":1,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/6974\/revisions"}],"predecessor-version":[{"id":6977,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/6974\/revisions\/6977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/6972"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=6974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=6974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=6974"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=6974"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=6974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}