{"id":7278,"date":"2026-03-31T11:31:05","date_gmt":"2026-03-31T02:31:05","guid":{"rendered":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=7278"},"modified":"2026-03-31T11:31:05","modified_gmt":"2026-03-31T02:31:05","slug":"elucidation-of-the-mechanisms-driving-pathogenicity-of-synovial-macrophages","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/elucidation-of-the-mechanisms-driving-pathogenicity-of-synovial-macrophages\/","title":{"rendered":"Elucidation of the Mechanisms Driving Pathogenicity of Synovial Macrophages"},"content":{"rendered":"<p>Hiroki Mukoyama<sup>1,2<\/sup>, Yusuke Takeuchi<sup>1,2<\/sup>, Daiya Ohara<sup>1,3<\/sup>, Yoonha Lee<sup>1<\/sup>, Hitomi Watanabe<sup>1<\/sup>, Hiroki Kato<sup>4<\/sup>, Gen Kondoh<sup>1<\/sup>, Akio Morinobu<sup>2<\/sup>, Keiji Hirota<sup>1,4<\/sup>*<\/p>\n<p>1) Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br \/>\n2) Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan<br \/>\n3) The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan<br \/>\n4) Institute of Cardiovascular Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany<\/p>\n<p><strong>Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis<\/strong><\/p>\n<p><em>Science Advances<\/em> (2026)\u00a0 <a href=\"http:\/\/doi.org\/10.1126\/sciadv.aec0986\">doi.org\/10.1126\/sciadv.aec0986<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hiroki Mukoyama1,2, Yusuke Takeuchi1,2, Daiya Ohara1,3, Yoonha Lee1, Hitomi Watanabe1, Hiroki Kato4, Gen Kondoh1, Akio Morinobu2, Keiji Hirota1,4* 1) Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. 2) Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 3) The Hakubi Center for Advanced [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":7300,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=7277","footnotes":""},"categories":[1],"tags":[],"labo":[22],"labo_en":[60],"class_list":["post-7278","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo-labo19","labo_en-labo19","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/7278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=7278"}],"version-history":[{"count":5,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/7278\/revisions"}],"predecessor-version":[{"id":7299,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/7278\/revisions\/7299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/7300"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=7278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=7278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=7278"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=7278"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=7278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}