{"id":8041,"date":"2026-10-01T10:49:47","date_gmt":"2026-10-01T01:49:47","guid":{"rendered":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=8041"},"modified":"2026-10-01T10:49:47","modified_gmt":"2026-10-01T01:49:47","slug":"post-8033","status":"publish","type":"post","link":"https:\/\/www.infront.kyoto-u.ac.jp\/en\/post-8033\/","title":{"rendered":"Step-by-step maturation mechanism of the binary toxin pore revealed by cryo-EM analysis"},"content":{"rendered":"<p><strong>Step-by-step maturation mechanism of the binary toxin pore revealed by cryo-EM analysis<\/strong><\/p>\n<p>Tomohito Yamada<sup>1<\/sup>, Ren Nakanishi<sup>1<\/sup>, Yukihiko Sugita<sup>2,3<\/sup>, Yuki Ninomiya<sup>1<\/sup>, Toru Yoshida<sup>1<\/sup>, Takeshi Noda<sup>2,3<\/sup>, Hideaki Tsuge<sup>1<\/sup><br \/>\n(1Faculty of Life Sciences, Kyoto Sangyo University; 2Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University; 3Laboratory of Supramolecular Structural Biology, Research Center for Infectious Diseases, Institute for Life and Medical Sciences, Kyoto University)<\/p>\n<p><em>Proceedings of the National Academy of Sciences of the United States of America (PNAS) (2026)<\/em><\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1073\/pnas.2627537123\">https:\/\/doi.org\/10.1073\/pnas.2627537123<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Step-by-step maturation mechanism of the binary toxin pore revealed by cryo-EM analysis Tomohito Yamada1, Ren Nakanishi1, Yukihiko Sugita2,3, Yuki Ninomiya1, Toru Yoshida1, Takeshi Noda2,3, Hideaki Tsuge1 (1Faculty of Life Sciences, Kyoto Sangyo University; 2Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University; 3Laboratory of Supramolecular Structural Biology, Research Center for Infectious Diseases, [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":8042,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/www.infront.kyoto-u.ac.jp\/?p=8033","footnotes":""},"categories":[1],"tags":[],"labo":[],"labo_en":[48],"class_list":["post-8041","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-achievements","labo_en-labo04","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/8041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/comments?post=8041"}],"version-history":[{"count":3,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/8041\/revisions"}],"predecessor-version":[{"id":8045,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/posts\/8041\/revisions\/8045"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media\/8042"}],"wp:attachment":[{"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/media?parent=8041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/categories?post=8041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/tags?post=8041"},{"taxonomy":"labo","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo?post=8041"},{"taxonomy":"labo_en","embeddable":true,"href":"https:\/\/www.infront.kyoto-u.ac.jp\/wp-json\/wp\/v2\/labo_en?post=8041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}