Institute for Frontier Life and Medical Sciences, Kyoto University

Department of Regeneration Science and Engineering

Lab. of Tissue Stem Cell Biology



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Research theme

We are interested in molecular and cellular mechanisms of organ development and regeneration, especially from an aspect of tissue stem ells and cell-cell interactions required for cellular proliferation and differentiation.
First project is to elucidate mechanisms of skeletal muscle regeneration. Adult skeletal muscle stem cells (MuSCs), the major cellular source for skeletal muscle regeneration, are kept cell cycle arrested in muscle tissues except when they break the quiescence upon myofiber injury or under pathogenic condition such as Duchenne Muscular Dystrophy (Fig.1).

[Fig.1] Muscle Stem Cells Regenerate Injured Skeletal Muscle


Key questions to be solved are as follows. (i) How are MuSCs established during development and growth after birth? (ii) What activates MuSCs and makes them to differentiate to muscle fibers? (iii) What makes MuSCs cell cycle arrested? (iv) How are inflammatory cells involved in muscle regeneration?

As a second project, we are investigating regulatory role of ADAM (A Disintegrin And Metalloprotease) family proteases in the ectodomain shedding during development and regeneration (Fig.2).

[Fig.2] Visualization of ectodomain shedding of Neureguin, a trans-membrane growth factor that regulates neuromuscular junction (synapse) formation

Third project is to know mechanisms of skeletal muscle atrophy caused by aging or cachexia and by the stay in space. We launched our zebrafish into the Space in order to clarify whether the microgravity causes muscle atrophy also in fish. If you are interested in this research, please visit zebrafishmuscle/.

Graduate Education

  • Graduate School of Medicine
  • Graduate School of Biostudies


  • Doctor course 5, Master course 1.

Contact Information

Person to Contact

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