Institute for Frontier Life and Medical Sciences, Kyoto University

Department of Regeneration Science and Engineering

Lab. of Immunology

Member

Professor Hiroshi Kawamoto (kawamoto∗infront.kyoto-u.ac.jp)
Associate Professor Masaki Miyazaki (mmiyazaki∗infront.kyoto-u.ac.jp)
Program-Specific Lecturer Keiko Iwaisako(iwaisako.keiko.3x*kyoto-u.ac.jp)
Assistant Professor Kyoko Masuda (kyoko.masuda∗infront.kyoto-u.ac.jp)
Program-Specific Assistant Professor Junji Uehori (uehori∗infront.kyoto-u.ac.jp)

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Research theme

The major aim of our laboratory is to elucidate the molecular mechanisms that regulate cell fate decisions in the process of lineage restriction from multipotent hematopoietic stem cells to unipotent progenitors. Among various events occurring during hematopoiesis, we are mainly focusing on the process towards the production of T cells. We are also interested in developmental process of thymic epithelial cells.

As another project, we have been developing an approach aiming to apply our culture method in clinical settings. Whereas cytotoxic T lymphocytes (CTLs) represent the most promising therapeutic avenue in cancer immunotherapy, adaptive transfer of antigen-specific CTLs has faced difficulty in efficient expansion of CTLs from patients in ex vivo culture. To solve this issue, we have proposed a strategy to use iPSC technology for cloning and expansion of tumor antigen specific CTLs; iPSCs produced from T cells (T-iPSCs) should inherit rearranged TCR genes, and thus all regenerated T cells from T-iPSCs should express the same TCR.


Figure 1 Main research projects

Figure 2 Cloning and expansion of killer T cells specific for tumor antigen using the iPS cell technology

Graduate Education

  • Graduate School of Science
  • Graduate School of Medicine

Students

  • Doctor course 6

Contact Information

Person to Contact Professor Hiroshi Kawamoto
TEL 075-751-3818
E-mail kawamoto∗infront.kyoto-u.ac.jp

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