Institute for Frontier Life and Medical Sciences, Kyoto University

Department of Biosystems Science

Lab. of Cellular Differentiation


Assistant Professor Shigenori Miura (s-miura∗
Assistant Professor Yusuke Arima (arima∗

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Research theme

We are aiming at the elucidation of molecular interactions and signaling networks underlying bone and cartilage formation. Our current research efforts are focused on the following studies: (1) Regulatory mechanism of endochondral bone formation initiated by vascular invasion into cartilaginous bone precursor; (2) Action mechanisms of cartilage-specific angiogenesis inhibitor Chondromodulin-I and tendon/ligament-specific angiogenesis inhibitor Tenomodulin, and their therapeutic applications for angiogenic diseases; (3) Identification of regulatory genes associated with chondrogenic differentiation; (4) Molecular mechanisms of tissue-specific transcription of tenomodulin gene; (5) Molecular analysis of regenerative repair of articular cartilage and tendons/ligaments. In addition, we implement materials engineering approaches to overcome problems associated with current technology for cell-based therapy, focusing on the followings: 1) semi-large scale production of islet-like cell aggregates from iPS cells. 2) Immunoprotection of transplanted islets. 3) Modification of cell surface with biomolecule-conjugated amphiphilic polymers. 4) Gaining deeper insights into the molecular events taking place at the interface between artificial materials and biological systems.

Graduate Education

  • Graduate School of Medicine
  • Graduate School of Engineering


  • Doctor course 1, Master course 2.

Contact Information

Person to Contact Assistant Professor Shigenori Miura
TEL 075-751-4608
E-mail s-miura∗

Replace the ∗ (asterisk) with @ (at mark).