Institute for Frontier Life and Medical Sciences, Kyoto University

Department of Biosystems Science

Lab. of Systems Virology


Professor Yoshio Koyanagi (ykoyanag∗
Lecturer Alexis Vandenbon(alexisvdb*

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Research theme

1) Replication of viral genome
Viruses infect and replicate in cells. This is one of the most significant characteristics of viruses. The mechanism of the infection event is a primary theme.

2) Regulation of HIV infection by host molecules
Virus cannot replicate without cells. Since many positive and negative host factors associated HIV replication have been identified, we investigate the mechanism of HIV infection from the aspect of Immunology and Virology.

3) Mechanism of HIV pathogenesis
HIV causes immunodeficiency in human. The mechanism of the immunodeficiency remains unclear. It has been analyzing how the immunodeficiency occurs using in vitro-cell culture models and in vivo-animal models. We developed a mouse system that human immune system is transplanted in SCID mouse and in this human-chimera mouse high level of HIV viremia can be reproduced (figure). We have been performing a series of above in vitro and in vivo experiments and also computational analyses based upon mathematical model.


Graduate Education

  • Graduate School of Medicine
  • Graduate School of Pharmaceutical Sciences
  • Graduate School of Biostudies


  • Doctor course 2, Master course 2.

Contact Information

Person to Contact Professor Yoshio Koyanagi
TEL 075-751-4813
E-mail ykoyanag∗

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