Institute for Frontier Life and Medical Sciences, Kyoto University

No. 1303 Extrinsic and Intrinsic regulation of stem cell fate

Date: Mar. 13, 2019 13:30~14:30
Room: Seminar Room, 1st floor, Bldg. #2 of Institute for Frontier Life and Medical Sciences, Kyoto University
Speaker: Shahragim Tajbakhsh
Professor
Stem Cells & Development Unit
Institut Pasteur, Paris
Title: Extrinsic and Intrinsic regulation of stem cell fate

Abstract

Regulation of skeletal muscle stem cells during homeostasis and regeneration involves the interplay of extrinsic and intrinsic cues. The mechanisms by which niche molecules and intrinsic factors regulate muscle stem cell quiescence and properties remain largely unknown. In a series of studies, we investigated Notch as a key mediator of muscle stem cell stability and fate. Notably, we found that Notch/RBPJ-bound regulatory elements are located adjacent to specific collagen genes in adult muscle stem cells, and investigated how extrinsic cues assure stem cell quiescence. In addition, we identified a microRNA pathway that is modulated by Notch, and that is required for stabilizing muscle stem cells in their niche by regulating the migration capacity of the muscle stem cell. These observations lead us to propose a two-step mechanism for niche occupancy by muscle stem cells. We have also developed protocols to follow asymmetric cell divisions directly in vivo. These results will be discussed in the context of histone turnover in stem cells.

(言語:英語 Language: English)

 

 

Invitator Lab. of  Growth Regulation System
 Ryoichiro Kageyama   (tel:075- 751-4011

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