京都大学 ウイルス・再生医科学研究所

第1312回 How does HTLV-1 hide? Dynamics of HTLV-1 transcriptional latency and reactivation

日時: 2020年1月27日 (月)15:00~16:00 

場所: 京都大学 ウイルス再生研 2号館(旧ウイルス研本館) 1階セミナー室 
演者: Charles R M Bangham博士
    Imperial College London
演題: How does HTLV-1 hide? Dynamics of HTLV-1 transcriptional latency and reactivation

Abstract:

It is now clear that the human leukaemia virus HTLV-1 is transcribed, like most human genes, in intermittent bursts.  Both the sense strand and the antisense strand of the HTLV-1 provirus are expressed in bursts, but the frequency and intensity of these bursts differs greatly between the two strands.  It is not yet fully understood what regulates the frequency, intensity and duration of these transcriptional bursts.  We have identified a number of factors that influence the burst frequency, including the genomic integration site of the provirus, the stress-responsive p38 MAP Kinase, polycomb repressive complex 1, cytosine methylation, hypoxia, and glycolysis.  Using single-molecule RNA fluorescence in situ hybridization and real-time imaging, we have developed a mathematical model of the transcriptional dynamics of HTLV-1.  We hypothesize that the chromatin architectural protein CTCF, which binds to the HTLV-1 provirus, confers a survival advantage on the virus by bringing the provirus near to actively transcribed regions of the host genome.  This hypothesis is now under test.                                                                                       (言語:英語 Language: English)

 

 

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