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Nov 06, 2025
Analysis of Memory Abnormalities in an Alzheimer’s Disease Mouse Model Using Computational Modeling

Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

eLife November 4, 2025.
https://doi.org/10.7554/eLife.105347.3

Mei-Lun Huang1, Yusuke Suzuki*1,2,5, Hiroki Sasaguri3,4, Takaomi C Saido3, Itaru Imayoshi*1,2,5

1: Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
2: Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
3: Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
4: Dementia Pathophysiology Collaboration Unit, RIKEN Center for Brain Science, Saitama, Japan
5: Laboratory of Deconstruction of Stem Cells, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan

*Corresponding author

Abstract

The research results conducted by Professor Imayoshi from Graduate School of Biostudies (Concurrent appointment: Professor, Institute for Life and Medical Sciences), Assistant Professor Suzuki from Graduate School of Biostudies (Collaborating Researcher, Institute for Life and Medical Sciences), and others have been published in “eLife.”

For more details, please see the link below.
https://www.lif.kyoto-u.ac.jp/e/research/research_results/cat30/2025-11-06/