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DEPARTMENT OF Regeneration Science and EngineeringLAB. OF Immunopathogenesis

Professor Yoshinaga Ito Professor

Yoshinaga Ito

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We study an interplay between immune system and self-organs/tissues, with a particular focus on its physiological roles and the mechanisms of disease development when the interaction becomes aberrant. We place autoimmunity and cancer immunology from an integrated perspective: both of them are ‘destruction of self-derived components by immune system’. We strive to discover key molecular pathways shared by both autoimmune diseases and cancer immunotherapy in order to develop innovative treatment arms for these devastating diseases.


Yoshinaga Ito


Immune reaction to self in health and diseases

We strive to understand physiological roles of self-recognition by immune system and how its dysregulation leads to life-threating illnesses such as autoimmune diseases and cancer. Our approach is to combine in depth mechanistic study using animal models and validation of the mechanisms by human samples.Our goal is to devise novel treatments based on the understanding of the molecular mechanisms of these diseases.

Novel target autoantigens and pathogenic mechanisms of autoimmune disease

By employing our own new technology, we will elucidate the whole repertoire of autoantigens critical for disease development in autoimmune diseases in order to establish antigen-specific therapeutics.