The research projects carried out by this group are concerned with post-translational events in the expression of genetic information. Specifically, the processes of protein translation, protein translocation across and integration into the membrane, membrane protein proteolysis/assembly, and the stress responses that are induced when these cellular processes are compromised, are investigated by combined molecular genetic, biochemical biophysical and structural approaches. We are attempting to understand the mechanism of proteostasis in the cell surfaces of bacteria such as E. coli and Vibrio species.