| Apr 13, 2026 Revealing the high-resolution structure of the Borna disease virus 1 nucleoprotein-RNA complex, a cause of fatal encephalitis |
Yukihiko Sugita (杉田征彦) *†, Yuya Hirai (平井悠哉) *†, Shinya H. Goto (後藤真也), Takuro Fujiwara (藤原拓朗), Keizo Tomonaga (朝長啓造), Takeshi Noda (野田岳志), Masayuki Horie (堀江真行) †
(* Co-first authors † Co-corresponding authors)
Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes
Science Advances DOI: https://doi.org/10.1126/
Published online: April 10, 2026, at 2:00 PM (EDT)
Abstract
Research findings from a collaborative team including Associate Professor Yukihiko Sugita (also affiliated with the Graduate School of Biostudies), Doctoral Student Shinya H. Goto (Graduate School of Biostudies), Doctoral Student Takuro Fujiwara (Graduate School of Medicine), Professor Keizo Tomonaga (also affiliated with the Graduate School of Medicine), and Professor Takeshi Noda (also affiliated with the Graduate School of Biostudies), together with Lecturer Yuya Hirai (School of Dentistry, Osaka Dental University) and Professor Masayuki Horie (Graduate School of Veterinary Science, Osaka Metropolitan University; also affiliated with the Osaka International Research Center for Infectious Diseases), were published in Science Advances.
For more details, please visit Kyoto University’s website.
https://www.kyoto-u.ac.jp/ja/research-news/2026-04-13
Figure: Conceptual overview of this study. By analyzing many complex states, the research group identified the structure of the nucleoprotein–RNA complex.