Date:	Nov. 28th, 2018 15:00~16:00
Room:	Seminar Room, 1st floor, Bldg. #2 of Institute for Frontier Life and Medical Sciences, Kyoto University
Speaker:	Ole Schmeltz Søgaard, MD PhD Associate Professor; Department of Infectious Diseases, Aarhus University Hospital, Denmark
Title:	Immunotherapy and Latency Reversal as Strategies to cure HIV infection

Abstract

The realization that prolonged combination antiretroviral treatment (cART) does not lead to eradication of HIV infection has spurred an impressive scientific effort in characterizing latent HIV reservoirs. This has improved our understanding of the intricate mechanisms that establish HIV latency and enable the virus to persist for decades evading host immune responses and potent cART. Many strategies are now being pursued in HIV-cure related research. This talk will discuss reactivation strategies that are being used for the eradication of HIV infection by turning on expression of latent HIV proviruses with emphasis on agents that are being tested in clinical trials. In addition, the use of immunotherapy and broadly neutralizing antibodies to boost HIV-specific immunity in recent and ongoing trials will also be discussed in detail. While the road to cure HIV is long and winding, recent findings from experiments in non-human primates suggest that combinations of such interventions might lead to long-term (S)HIV remission.

 

（Language : English）

 

 

Invitator	Lab. of Infectious Disease Model
	Hirofumi Akari  (tel:075- 751-4798)