日時：	2018年11月28日 15:00~16:00
場所：	京都大学ウイルス再生研2号館（旧ウイルス研本館）1階セミナー室
演者：	Ole Schmeltz Søgaard, MD PhD Associate Professor; Department of Infectious Diseases, Aarhus University Hospital, Denmark
演題：	Immunotherapy and Latency Reversal as Strategies to cure HIV infection

講演要旨

The realization that prolonged combination antiretroviral treatment (cART) does not lead to eradication of HIV infection has spurred an impressive scientific effort in characterizing latent HIV reservoirs. This has improved our understanding of the intricate mechanisms that establish HIV latency and enable the virus to persist for decades evading host immune responses and potent cART. Many strategies are now being pursued in HIV-cure related research. This talk will discuss reactivation strategies that are being used for the eradication of HIV infection by turning on expression of latent HIV proviruses with emphasis on agents that are being tested in clinical trials. In addition, the use of immunotherapy and broadly neutralizing antibodies to boost HIV-specific immunity in recent and ongoing trials will also be discussed in detail. While the road to cure HIV is long and winding, recent findings from experiments in non-human primates suggest that combinations of such interventions might lead to long-term (S)HIV remission.

 

（言語：英語）

 

 

主　催	京都大学ウイルス・再生医科学研究所
連絡先	ウイルス感染症モデル分野明里 宏文（TEL:075-751-4798）