HOME > SEMINAR / EVENT > No.1313 HTLV-1 Molecular Pathogenesis: From Hbz to CTCF
Feb 5, 2020
No.1313 HTLV-1 Molecular Pathogenesis: From Hbz to CTCF
Date: February. 5, (Wed.) 2020 16:00~17:00
Room: Seminar Room,1st floor of Bldg. No.2 of Institute for Frontier Life and Medical Science, Kyoto University
Speaker: Dr. Patrick Green
The Ohio State University
Title: HTLV-1 Molecular Pathogenesis: From Hbz to CTCF


Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact mechanism(s) through which latency and disease progression are regulated are not fully understood. Recent work by the Green lab has focused on the Hbz gene and a CCCTC-binding factor (CTCF) site located within the overlapping p12 (sense) and Hbz (antisense) genes of the HTLV-1 genome. CTCF has been shown to play a role in organization of higher-order chromatin structure, gene expression, genomic imprinting and serve as a barrier to epigenetic modification. An overview of results from molecular and animal model approaches employing an infectious HTLV-1 molecular clone and derivatives will be presented to better understand the role of Hbz and the vCTCF-BS in HTLV-1 pathogenesis.

(Language: English)



Invitator: Laboratory of Virus Control (Masao Matsuoka)

Laboratory of Ultrastructural Virology(Takeshi Noda)