Date:	February. 5, (Wed.) 2020 16:00~17:00
Room:	Seminar Room,1st floor of Bldg. No.2 of Institute for Frontier Life and Medical Science, Kyoto University
Speaker:	Dr. Patrick Green The Ohio State University
Title:	HTLV-1 Molecular Pathogenesis: From Hbz to CTCF

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact mechanism(s) through which latency and disease progression are regulated are not fully understood. Recent work by the Green lab has focused on the Hbz gene and a CCCTC-binding factor (CTCF) site located within the overlapping p12 (sense) and Hbz (antisense) genes of the HTLV-1 genome. CTCF has been shown to play a role in organization of higher-order chromatin structure, gene expression, genomic imprinting and serve as a barrier to epigenetic modification. An overview of results from molecular and animal model approaches employing an infectious HTLV-1 molecular clone and derivatives will be presented to better understand the role of Hbz and the vCTCF-BS in HTLV-1 pathogenesis.

(Language: English)

 

 

Invitator：	Laboratory of Virus Control （Masao Matsuoka） Laboratory of Ultrastructural Virology（Takeshi Noda） （TEL:075-751-4048・4019）