日時：	2020年2月5日（水）16：00～17：00
場所：	京都大学 ウイルス再生研 2号館(旧ウイルス研本館） 1階セミナー室
演者：	Patrick Green博士 The Ohio State University
演題：	HTLV-1 Molecular Pathogenesis: From Hbz to CTCF

講演要旨

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact mechanism(s) through which latency and disease progression are regulated are not fully understood. Recent work by the Green lab has focused on the Hbz gene and a CCCTC-binding factor (CTCF) site located within the overlapping p12 (sense) and Hbz (antisense) genes of the HTLV-1 genome. CTCF has been shown to play a role in organization of higher-order chromatin structure, gene expression, genomic imprinting and serve as a barrier to epigenetic modification. An overview of results from molecular and animal model approaches employing an infectious HTLV-1 molecular clone and derivatives will be presented to better understand the role of Hbz and the vCTCF-BS in HTLV-1 pathogenesis.

(言語:英語　Language: English)

 

 

主　催：	京都大学ウイルス・再生医科学研究所
連絡先：	ウイルス制御分野（松岡雅雄）微細構造ウイルス学分野（野田岳志） （TEL:075-751-4048・4019）