日時：	2026年3月5日（木）15：00～16：00
場所：	医生研1号館1階セミナー室（134室） Conference Room (Room 134), 1st Floor, Bldg. No.1
演者：	Hideki Tatsukawa, Ph.D. Assistant Professor Graduate School of Pharmaceutical Sciences, Nagoya University
演題：	Protein crosslinking reactions governing organ stiffening: Molecular mechanisms and control strategies for fibrosis

講演要旨

Tissue injury typically triggers inflammation followed by repair, and wounds usually heal completely. However,
when damage is severe or repetitive, the repair program can break down, leading to excessive accumulation of
the extracellular matrix (ECM) and progressive tissue stiffening. Similar maladaptive repair can also occur
under chronic inflammatory conditions, resulting in fibrosis and scarring. Fibrosis is a common pathological
feature shared by multi-organ diseases such as liver cirrhosis, kidney failure, and pulmonary fibrosis, and is
estimated to account for approximately ~ 45% of deaths. In this seminar, I will focus on protein crosslinking
enzymes that catalyze the formation of isopeptide covalent bonds between proteins, and introduce our analyses
of the molecular mechanisms by which these enzymes contribute to fibrotic pathogenesis through macrophage
phenotypic changes, fibroblast activation, and qualitative alterations in ECM properties, together with potential
control strategies targeting these processes.

HidekiTatsukawa_20260305

Host:
Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp