日時：	15:00 - 16:30, July 25 (Tue), 2023
場所：	Room 501, 5th floor, Bldg. #3 Institute for Life and Medical Sciences, Kyoto University
演者：	Dr. Yuji Hirono Department of Physics, Kyoto University
演題：	Robust perfect adaptation in chemical reaction systems and network topology

講演要旨

Maintaining stability is a critical issue for living systems. Robust perfect adaptation (RPA) refers to a phenomenon in which some output variables of a system can reach and maintain certain values despite external disturbances in a robust manner. RPA helps the survival of living systems in unpredictable environments, and as such there are numerous examples of biological implementations of this feature. However, complex interaction patterns among components in biochemical systems pose a significant challenge in identifying RPA properties and associated regulatory mechanisms.In this talk, we try to elucidate the essential role of network topology in the phenomenon of RPA [1]. We argue that all the RPA properties in a deterministic chemical reaction system can be fully identified by topological characteristics of subnetworks. This is accomplished by proving that an RPA property is represented by a subnetwork with certain topological features. This connection is exploited to show that these structures generate all kinetics-independent RPA properties, allowing us to systematically identify all RPA properties by enumerating these subnetworks. Furthermore, we pinpoint the integral feedback controllers that work in concert to realize each RPA property, casting our results into the control-theoretic paradigm of the Internal Model Principle. We also generalize the regulation problem to the multi-output scenario where the target values belong to a manifold of nonzero dimension, and provide a sufficient condition for this phenomenon.（Language: English）

 

contact: Takashi Okada
Laboratory of Mathematical Biology,
Institute for Life and Medical Sciences,
Kyoto University
Email: okada.Takashi.3z＊infront.kyoto-u.ac.jp（＊を@に変えてください。）
Tel: 075-751- 4780