日時：	2025年7月24日（木）13：30～15：00
場所：	医生物学研究所　２号館１階セミナー室（104室） Seminar Room (104), 1st floor, Bldg. #2 Institute for Life and Medical Sciences, Kyoto University
演者：	Polly Yu Department of Mathematics University of Illinois Urbana-Champaign
演題：	Necessary Network Structures for Dynamical Properties of Biochemical Systems

講演要旨

It is often said that certain network motifs are necessary for interesting
dynamical properties. For example, positive feedback is said to be a necessary
condition for sustained oscillation, or that incoherent feedforward is necessary
for biphasic dose-response curves. An issue is that different communities are
often looking at different networks, while using the same terminology. We will
compare the diagram for activation/inhibition pathways in cellular signalling and
the interaction graph for the Jacobian matrix. As an application, we consider a
model for the activation of T-cells, and prove that the biphasic dose-response
curve of cytokines necessarily implies either an incoherent feedforward loop, or
a mixture of both types of feedback loops. Time permitting, we will look at
reaction diagrams (species-reaction graphs or Petri nets), and discuss the
nuances of moving between such a diagram and the Jacobian interaction graph.(Language: English)

Seminar20250724

contact: Atsushi Mochizuki
Laboratory of Mathematical Biology,
Institute for Life and Medical Sciences,
Kyoto University
Email: mochi[@]infront.kyoto-u.ac.jp
Tel: 075-751-4612

※本セミナーは、Frontier Topology Seminarとの共催です。