日時：	2025年10月31日（金）14：00～15：00
場所：	京都大学医生物学研究所　医生研１号館１階会議室（134室） Conference Room (Room 134), 1st Floor, Bldg. No.1
演者：	Kotaro Hirano, Ph.D. Assistant Professor Department of Integrative Physiology School of Pharmaceutical Sciences, University of Shizuoka
演題：	Mechanosensitive ion channels as biophysical sensors in muscle stem cells

講演要旨

The ability of adult tissues to regenerate relies on how stem cells precisely sense their environment and respond with the correct fate. Mechanical forces generated by routine tissue activity and injury are emerging as potent regulators of stem-cell activation. Yet, the molecular mechanisms by which stem cells decode these physical cues remain poorly understood. Skeletal muscle exhibits a strong regenerative capacity supported by muscle stem (satellite) cells, which reside between the myofiber and basal lamina. In response to muscle damage, satellite cells exit dormancy, expand, and commit to myogenic differentiation to rebuild functional tissue. However, the sensors that convert mechanical input into specific intracellular programs have not been fully defined.
To address this, mechanosensitive ion channels enriched in satellite cells were investigated using satellite cell–specific genetic approaches. These analyses revealed that multiple channels, including PIEZO1, cooperatively regulate sequential transitions of satellite cell behavior through distinct mechanisms. In this seminar, recent findings on metal-ion–dependent mechanosensing and a previously unrecognized mechanosignaling axis in muscle stem cells will be introduced, along with their physiological significance during muscle regeneration.

20251031_KotaroHirano

Host:
Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp