日時：	2025年11月12日（水）11：00～12：00
場所：	南部総合研究１号館・医生研１号館　１階共通セミナー室３（127室）
演者：	Jiliang Li, M.D. & Ph.D. Professor, Department of Biology Indiana University Indianapolis
演題：	STAT3 in Mechanotransduction and Bone Healing

講演要旨

Signal Transducer and Activator of Transcription 3 (STAT3) is a key transcription
factor that integrates biochemical and biomechanical cues to regulate bone remodeling and
repair. Emerging evidence indicates that STAT3 serves as a crucial mediator
of mechanotransduction, linking external mechanical stimuli to intracellular gene expression
that governs osteogenesis, angiogenesis, and tissue regeneration. Using conditional STAT3
knockout mouse models, studies have demonstrated that loss of STAT3 in osteoblasts or
osteocytes leads to impaired bone formation, reduced responsiveness to mechanical loading.
Conversely, mice with STAT3 overexpression display enhanced bone formation and
accelerated bone healing. Elevated STAT3 signaling promotes osteoblast differentiation,
increases bone formation rate, and improves callus maturation following injury. Together,
these genetic models highlight STAT3 as a central regulator of bone mechanotransduction
and bone repair, acting as a molecular hub that translates mechanical and cytokine signals
into coordinated transcriptional programs. Modulating STAT3 activity – either through
genetic or pharmacologic means – offers a promising strategy to enhance skeletal adaptation
and promote fracture healing in pathological conditions where mechanosensitivity is
compromised.

20251112(49thBiomechSeminar)Jilliang Li

連絡先：京都大学 医生物学研究所 バイオメカニクス分野
安達　秦治
adachi[@]infront.kyoto-u.ac.jp