日時：	2025年12月17日（水）15：00～16：00
場所：	医生研２号館１階セミナー室（104室）
演者：	Hidenobu Miyazawa Research Staff Scientist　EMBL Heidelberg
演題：	Beyond Energy and Growth: A Signaling Role of Metabolism in Developmental Timing

講演要旨

How metabolism impacts cell fate decisions during development and disease is a fundamental
yet unresolved question. It is increasingly recognized that metabolism plays an important role
beyond fueling biological processes, regulating gene expression and signal transduction.
However, due to its essential role in cellular homeostasis, it remains a key challenge to reveal
how metabolism exerts a signaling function. To address this challenge, we are investigating the
role of glycolysis using mouse embryo axis segmentation as an experimental model, which offers
a unique opportunity to study the impact of metabolism on signaling in real time and in a
quantitative manner. In this seminar, I will present our recent discovery that the glycolytic
metabolite fructose 1,6-bisphosphate (FBP) has a noncanonical signaling role in embryo axis
segmentation. We show that FBP controls the period of the segmentation clock – a molecular
clock controlling periodic axis segmentation – via Wnt signaling. Critically, we provide evidence
that this FBP-Wnt signaling axis can be decoupled from bioenergetic and biosynthetic roles of
glycolysis. At the end of my talk, I will discuss potential mechanisms of this signaling axis and its
implications for development in physiological contexts.

20251217_3rd mechanosensory physiology seminar（Hidenobu Miyazawa氏_EMBL Heidelberg）

Host: Keiko Nonomura(nonomura_keiko[@]infront.kyoto-u.ac.jp)