日時：	2025年12月2日（火）　16：00～17：00
場所：	京都大学 医生物学研究所 南部総合研究１号館・医生研１号館 １階 共同セミナー室３ https://www.infront.kyoto-u.ac.jp/en/access/
演者：	Dr. Neil Lin Mechanical and Aerospace Engineering Department Bioengineering Department Department of Urology, David Geffen School of Medicine University of California, Los Angeles, USA
演題：	Biophysical Regulation of Epithelial Cell Crowding

講演要旨

Epithelial cells line every organ in the body and form the front line of
many essential physiological processes. During development, wound healing, and
tissue repair, these cells become crowded as they migrate and proliferate to close
gaps and restore integrity. As crowding increases, the tissue gradually stiffens and
transitions from a fluid-like to a solid-like state. This process, often described
through the jamming transition framework, captures how cell density, shape, and
movement determine collective behavior. While the physical parameters of
jamming are now well characterized, the molecular events that control them are
still coming into focus. In this talk, I will begin by describing how epithelial cells
use glucose metabolism to regulate their motility during jamming. Next, I will
explore how variations in cell morphology arise within dense monolayers and how
these differences shape gene expression. I will end by discussing how artificial
intelligence can reveal hidden relationships among these physical and molecular
factors, and how such insights may deepen our understanding of cancer and tissue
organization.（講演言語：英語）

20251202(50thBiomechSeminar)NeilLin

主催：一般社団法人 日本機械学会 バイオエンジニアリング部門
協賛：京都大学 医生物学研究所 バイオメカニクス分野
連絡先：京都大学 医生物学研究所 牧功一郎 maki[@]infront.kyoto-u.ac.jp