| 2024年9月19日 【 第四回 ナノ生物流体工学セミナー】Research Introduction & Overview of the Strategic direction for the Global R&D projects |
| 日時： | 2024年9月19日（木）11：00～12：00 |
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| 場所： | 医生物学研究所 医生研１号館１階会議室（134室） Conference Room (134) 1st floor, Bldg No.1 of LiMe |
| 演者： | Min-Ho Lee School of Integrative Engineering, Chung-Ang University |
| 演題： | Research Introduction & Overview of the Strategic direction for the Global R&D projects |
講演要旨
In this presentation, I will discuss the results obtained from our work on electrochemical biosensors. Specifically, I will highlight the development of a duplex biosensing platform for the quantitative detection of biomarkers, where we utilized highly conductive nanomaterials in combination with customized electrodes. One of our key findings includes the modification of electrodes using transition metal dichalcogenides (TMDs) or graphene heterostructures. These developed sensors demonstrated enhanced sensitivity and selectivity, showing excellent correlation with commercially available standard methods. For the multiplexed and sensitive detection of miRNAs in diagnostic applications, we introduced an innovative strategy combining MXene-based electrochemical signal amplification with a duplex-specific nuclease (DSN)-based system. This approach enabled rapid, attomolar-level, simultaneous quantification of multiple miRNAs on a single platform in real samples. Additionally, to further improve sensitivity for detecting low levels of miRNAs, we developed a novel method called ‘relay-race amplification.’ This technique synergistically combines a 3-way junction structure with signal amplification using gold nanoparticles conjugated with multiple signaling labels. Following the presentation of my research, I will briefly introduce the direction and objectives of a global R&D project being promoted by the Korea Office of Science and Technology Innovation. This initiative aims to establish collaborative research centers within leading global research institutes and universities, with the goal of advancing cutting-edge research in promising technology areas. Specifically, I will discuss the plans for promoting joint research in the advanced biotechnology field and outline the strategies being implemented to facilitate these collaborative efforts.
Keywords: Electrochemical method, multiplex biosensor, RNA detection, immunoassay
問い合わせ先：医生物学研究所 ナノ生物工学分野 新宅博文（shintaku[@]infront.kyoto-u.ac.jp）