| 2024年11月12日 【7th nanobiofluids seminar】Molecular imaging using optics-free spatial DNA networks |
| 日時： | 2024年11月12日（火）10：30～12：00 |
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| 場所： | 医生物学研究所 １号館１階会議室（134室） Conference room (Room 134), Bldng No.1 |
| 演者： | Ian Hoffecker Group Leader, Molecular Programming Group Science for Life Laboratory Department of Gene Technology, KTH Royal Institute of Technology Stockholm, Sweden |
| 演題： | Molecular imaging using optics-free spatial DNA networks |
講演要旨
Spatial-omics methods seek to resolve the spatial locations of biomolecules like mRNA or
proteins without optics, using instead spatial information encoded in DNA sequences. Current methods
relying on printed array-based spatial omics methods depend on acquiring a spatial reference map prior to
biomolecule capture and sequencing, involving either top-down assignment of spatial positions via arrayprinting
or in situ sequencing on random arrays. Sequencing-based microscopy is an emerging alternative
to which seeks to embed recoverable spatial information in the topology of DNA barcode networks,
formed through self assembly in the sample or space of interest in 2D or 3D. Networks able to
communicate spatial information exhibit spatial coherence, or a correlation between topological and
Euclidean distances. Sequencing-based microscopy methods offer a novel route toward image formation,
potentially circumventing limitations such as the requirement of planarity in classical optics or array based
spatial omics.
Host: Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp