| 2025年6月27日 【15th nanobiofluids seminar】Blood flow-dependent force parameters instruct endocardial cell identity for the heart morphogenesis |
| 日時： | 2025年6月27日（金）14：00～15：00／2025 June 27th, 14:00-15:00 |
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| 場所： | 医生物学研究所 医生研１号館１階会議室（134室） Conference Room (Room 134), 1st Floor, Bldg. No.1 |
| 演者： | Hajime Fukui, Ph.D. Associate Professor Division of Biomechanics and Signaling Institute of Advanced Medical Sciences Tokushima University |
| 演題： | Blood flow-dependent force parameters instruct endocardial cell identity for the heart morphogenesis |
講演要旨
Developing cardiovascular systems use mechanical forces, such as fluid shear force, pressure, and contractile forces, to shape tissue form and function. We recently identified that mechano-responsive signals happen in both spatial and temporal manner during the cardiac lumen formation in zebrafish. However, the mechanism by which the cells appropriately regulate mechanical signals in response to the continuous forces is still unclear. In our lab, we aim to elucidate how the structured cardiac lumen is organized for functional blood circulation, focusing on the “forces generated from blood flow” and “biological signals” during the lumen formation. In this seminar, I will present a technique that directly manipulates physical forces and the biological signal outputs by quantitative approaches in zebrafish embryos.
Host: Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp