日時：	2025年8月11日（月）14：00～15：00
場所：	医生研2号館1階セミナー室（104室） Seminar Room (Room 104), 1st Floor, Bldg. No.2
演者：	SJ Claire Hur, Ph.D. Assistant Professor Department of Mechanical Engineering Whiting School of Engineering, Johns Hopkins University
演題：	Microfluidic Strategies for Single-Cell Manipulation in Personalized Medicine

講演要旨

Variability in patient responses to treatment highlights the need for truly individualized therapeutic approaches.
Gaining a clear, quantitative picture of single-cell behavior is key to understanding and addressing this
heterogeneity. In the Hur laboratory, we apply fundamental principles of fluid mechanics to develop
microfluidic platforms that gently probe and guide individual cells, shedding light on subtle functional
differences. Our efforts focus on using hydrodynamic forces to sort and position cells based on measurable
physical traits—such as size and deformability—through carefully designed inertial microfluidic channels.
These channels allow us to isolate relatively uniform cell subsets under mild flow conditions, which improves
consistency in downstream assays. We have also combined vortex‐based inertial focusing with on-chip
electroporation, creating a workflow that holds cells at specific locations for reliable molecular delivery before
releasing them on demand. This approach enables efficient, repeatable transfection of primary cells with
minimal mechanical stress. Our platforms aim to deliver accessible, scalable tools for applications in cancer
research, immunology, gene therapy, and regenerative medicine. These systems support reliable target-cell
separation, and sequential multimodal delivery—offering modest yet meaningful advances toward more
personalized treatment strategies.

20250811_ProfClaireHur_flyer

Host: Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp