| 2025年10月27日 【18th nanobiofluids seminar】Regulatory mechanisms of caspase activation enabling diverse physiological functions |
| 日時： | 2025年10月27日（月）16：00～17：00 |
|---|---|
| 場所： | 京都大学 芝蘭会館 山内ホール https://www.med.kyoto-u.ac.jp/facilities/shiran/access/ |
| 演者： | Masayuki Miura Ph.D. Director-general, National Institute for Basic Biology |
| 演題： | Regulatory mechanisms of caspase activation enabling diverse physiological functions |
講演要旨
Abstract
Caspases are cysteine proteases essential for apoptosis. Because apoptosis in vivo occurs sporadically and is executed rapidly, it has been difficult to capture these events directly. We have investigated the physiological functions of caspases using in vivo imaging of caspase activation combined with genetic approaches. Our studies revealed that caspases contribute to morphogenetic movements and to the rapid switching of morphogen signaling through the removal of signaling centers during neural development. Caspase also plays a role in rapidly eliminating cells that fail to differentiate during neural development, thereby contributing to the formation of the alignment pattern of the external sensory organs. Furthermore, caspases were shown to actively participate in inflammation. As our next challenge, we aim to elucidate the precise regulation of cellular functions by caspases by investigating caspase activation at specific intracellular locations. In this seminar, I will introduce recent studies on the mechanisms of caspase activation at specific intracellular locations and their physiological functions.
Biography
Dr. Masayuki Miura is a Director-general of the National Institute for Basic Biology, Okazaki. He earned his B.Sc. and M.Sc. at the Department of Biology, Tokyo Metropolitan University. He completed his Ph.D. at Biological Chemistry from Osaka University. He worked at National Institute for Basic Biology as a Post-Doc, at Keio University School of Medicine as an Instructor, at Massachusetts General Hospital as a Post-Doc, at Institute of Basic Medical Sciences, Tsukuba University as a Lecturer, at Graduate School of Medicine, Osaka University as an Associate Professor, at Brain Science Institute, RIKEN as a Team Leader, and at Graduate School of Pharmaceutical Sciences, the University of Tokyo as a Professor. Dr. Miura served as Dean of the Graduate School of Pharmaceutical Sciences at the University of Tokyo and has been a Research Supervisor for PRESTO at JST.
Host:
Akifumi Shiomi, Shiomi.akifumi.5v[@]kyoto-u.ac.jp
Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp