日時：	2026年6月5日（金）16：00～17：00
場所：	京都大学 医生物学研究所 南部総合研究1 号館・医生研1 号館 1 階セミナー室3（127室） URL：https://www.kyoto-u.ac.jp/ja/about/facilities/campus/kyoshokuin/nanbu/seminar
演者：	Yuika Ueda, Ph.D. Specially Appointed Researcher (JSPS PD) Department of Mechanical Science and Bioengineering Graduate School of Engineering Science, The University of Osaka
演題：	Cellular adaptability and mechanical homeostasis

講演要旨

Living cells adapt their internal structures to maintain mechanical
homeostasis in response to environmental cues. However, the physical principles
linking robust macroscopic structural adaptations to the underlying microscopic
fluctuations remain elusive. Here, we elucidate the physical basis of cellular
adaptability by examining both structural phase transitions and active nonequilibrium
fluctuations. We reveal that actin reorganization in response to substrate stiffness,
observed even in senescent fibroblasts, arises from a hierarchy of phase transitions
dictated by energy and entropy competition. This statistical mechanical framework
reveals how physical constraints guide distinct cytoskeletal orders. Furthermore, to
understand how cells maintain this adaptability in highly fluctuating environments,
we developed a quantitative framework to isolate active functional fluctuations from
thermal noise. Integrating fluorescence correlation spectroscopy with theoretical
analyses, we reveal that these nonthermal fluctuations are predominantly driven by
actomyosin activity. We also show that cellular senescence reshapes the fluctuation
landscape, where a reduction in fluctuation diversity mechanistically links to the
diminished adaptive capacity of senescent cells. Together, our findings reveal how
physical constraints and active regulation collaboratively maintain mechanical
homeostasis and govern the physiological state of living cells.（講演言語：日本語　Language:Japanese）

The 51st Biomechanics Seminar

Host
京都大学 医生物学研究所 安達 泰治 adachi[@]infront.kyoto-u.ac.jp