日時：	2026年9月25日（金）16：00～17：00
場所：	医生物学研究所　医生研１号館１階会議室（134室） Conference Room (#134), 1st Floor, Bldg. No.1
演者：	Martin Bastmeyer, Ph.D. Professor, Head of the Department Zoological Institute, Cell- and Neurobiology Karlsruhe Institute of Technology (KIT), Germany
演題：	3D Cellular Microenvironments to Study Cell Mechanics（講演言語：英語/Language：English）

講演要旨

Cell behavior and differentiation are not only influenced by biochemical cues but also by physical properties like adhesive geometry, topography, and stiffness of the 3D extracellular environment. Correspondingly, cells exert, sense, and respond to physical forces. I will discuss how 3D laser nanoprinting can be applied to design 3D cellular microenvironments with defined geometries and adjustable flexibility to study the interplay between extracellular physical factors and cell function in a systematic approach. Measurements of cell adhesion forces in relation to adhesion geometry are also feasible. In collaboration with chemists we have developed stimuli-responsive resists for 3D printing. These hydrogels change their mechanical properties upon external stimuli and have great potential for applications to study cellular mechanobiology. We have manufactured a miniaturized device that can be used to mechanically stretch single cells in a well-defined temporal and spatial manner and to simultaneously measure cellular contraction forces. In combination with knockout cell lines of proteins involved in cellular force production (e.g., non-muscle myosin II isoforms, alpha-actinin isoforms) this system will allow to study the molecular basis and regulation of force generation by non-muscle cells.

20260925_52ndBiomechSeminar_Martin_Bastmeyer (KIT)

Host:
LiMe, Kyoto University
Masahiro Kumeta (kumeta.masahiro.4r[@]kyoto-u.ac.jp)
Taiji Adachi (adachi[@]infront.kyoto-u.ac.jp)