HOME > About our laboratory > LAB. OF Tissue Homeostasis

DEPARTMENT OF Biosystems ScienceLAB. OF Tissue Homeostasis

Professor Fumiko Toyoshima Professor

Fumiko Toyoshima

  • Website


Our body changes its form and function depending on the life stage and lifestyle to maintain homeostasis. During pregnancy, various maternal organs such as the brain, liver, thymus, mammary gland, and skin are reorganized to accommodate fetus growth. In aging and obesity, tissue degeneration along with chronic inflammation is induced. In our laboratory, we aim to elucidate the mechanism of organ remodeling that accompanies physiological changes in the body, and to understand the mechanism that maintains the homeostasis of the body throughout the life stage. We are also aiming to develop new regenerative medical technologies and therapeutic agents based on the mechanism of physiological organ remodeling.
For information on bioinformatics technology development, please see the link of Associate Professor Alexis Vandenbon.


Fumiko Toyoshima

Alexis Vandenbon

Ryo Ichijyo


Tissue remodeling in physiological changes and medical application

Our laboratory is studying the physiological organ remodeling during pregnancy, obesity, and aging. We aim to clarify the mechanism by which heterologous cell networks such as blood vessels / nerves / immune / stromal / epithelial cells reorganize tissues and organs in cooperation with mechanofields and humoral factors in tissues. Based on the mechanism of the physiological organ remodeling, we are developing new medical technologies and therapeutic agents that contribute to damaged tissue repair and anti-aging. We are also investigating the interface between maternal organ remodeling and fetal development.

Maternal organ remodeling during pregnancy

Elucidation of the mechanism of maternal organ remodeling during pregnancy by using combining methods such as genetically modified mice, single-cell gene expression analysis, in vivo imaging, and mechanical analysis. In particular, we are focusing on the maternal skin and liver, which rapidly expand during pregnancy, and the crosstalk between maternal organ remodeling and fetal growth.

Tissue deterioration in aging and obesity

Studying the degenerative mechanism of skin in aging and obesity from the viewpoint of tissue stem cells, mechanobiology, and chronic inflammation. We aim to develop anti-aging technology that controls the stem cells and microenvironment that surround them.

Development of treatments and drugs for tissue repair and regeneration

Based on the mechanism of the physiological organ remodeling in pregnancy, aging, and obesity, we are conducting research on compounds, bioactive peptides, and cell therapies that promote damaged tissue repair. We are also developing gene targeting technology for gene therapy.