MESSAGE FROM THE LAB
Tissue remodeling in physiological changes and medical application
Our laboratory is studying the physiological organ remodeling during pregnancy, obesity, and aging. We aim to clarify the mechanism by which heterologous cell networks such as blood vessels / nerves / immune / stromal / epithelial cells reorganize tissues and organs in cooperation with mechanofields and humoral factors in tissues. Based on the mechanism of the physiological organ remodeling, we are developing new medical technologies and therapeutic agents that contribute to damaged tissue repair and anti-aging. We are also investigating the interface between maternal organ remodeling and fetal development.
Maternal organ remodeling during pregnancy
Elucidation of the mechanism of maternal organ remodeling during pregnancy by using combining methods such as genetically modified mice, single-cell gene expression analysis, in vivo imaging, and mechanical analysis. In particular, we are focusing on the maternal skin and liver, which rapidly expand during pregnancy, and the crosstalk between maternal organ remodeling and fetal growth.
Tissue deterioration in aging and obesity
Studying the degenerative mechanism of skin in aging and obesity from the viewpoint of tissue stem cells, mechanobiology, and chronic inflammation. We aim to develop anti-aging technology that controls the stem cells and microenvironment that surround them.
Development of treatments and drugs for tissue repair and regeneration
Based on the mechanism of the physiological organ remodeling in pregnancy, aging, and obesity, we are conducting research on compounds, bioactive peptides, and cell therapies that promote damaged tissue repair. We are also developing gene targeting technology for gene therapy.
Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a
A clustering-independent method for finding differentially expressed genes in single-cell transcriptome data
Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation