日時：	2019年3月13日 13:30～14:30
場所：	京都大学 ウイルス再生研２号館 (旧ウイルス研本館)1階セミナー室
演者：	Shahragim Tajbakhsh Professor Stem Cells & Development Unit Institut Pasteur, Paris
演題：	Extrinsic and Intrinsic regulation of stem cell fate

講演要旨

Regulation of skeletal muscle stem cells during homeostasis and regeneration involves the interplay of extrinsic and intrinsic cues. The mechanisms by which niche molecules and intrinsic factors regulate muscle stem cell quiescence and properties remain largely unknown. In a series of studies, we investigated Notch as a key mediator of muscle stem cell stability and fate. Notably, we found that Notch/RBPJ-bound regulatory elements are located adjacent to specific collagen genes in adult muscle stem cells, and investigated how extrinsic cues assure stem cell quiescence. In addition, we identified a microRNA pathway that is modulated by Notch, and that is required for stabilizing muscle stem cells in their niche by regulating the migration capacity of the muscle stem cell. These observations lead us to propose a two-step mechanism for niche occupancy by muscle stem cells. We have also developed protocols to follow asymmetric cell divisions directly in vivo. These results will be discussed in the context of histone turnover in stem cells.

(言語：英語　Language: English)

 

 

主　催	京都大学ウイルス・再生医科学研究所
連絡先	増殖制御システム分野　影山　龍一郎 （TEL:075-751-4011）