日時：	2023年11月13日（月）16：00～17：00
場所：	京都大学医生物学研究所　医生研3号館　3階セミナー室A 3F Seminar room A, Bldg. #3 of Institute for Life and Medical Sciences (LiME)
演者：	Dr. Jiri Zahradnik Junior PI at 1st Medical Faculty, Charles University, Prague, Czech Republic
演題：	Plasticity of PPls and its implication for SARS-CoV2 Spike's RBD domain and ACE2 interaction

講演要旨

AlfaFold2 and RossettaFold, advanced protein structure predictors, confidently forecast protein structures. Predicting protein binding, however, is more complex due to varying concentrations and affinities. An even more challenging task is the plasticity, inherently informing us about all possible solutions and their parameters for given interaction.
Apart from the structural similarity, the interface of SARS-CoV-2 -ACE2 is composed of different amino acids from that of the RBD of SARS-Co V. While both RBDs bind identical location, mostly helix one on the ACE2, they differ in 11 interface residues, and the new variants are similarly different. Parallel solutions for the same interaction suggest high interface plasticity. In my talk, I will describe how current in vitro evolution techniques can help explain this observed plasticity and what we have learned about protein interface evolution in general.

(開催言語：英語 Language:English)

A.MED新興・再興感染症に対する革新的医薬品等開発推進研究事業

「新型コロナウイルス感染症の克服に向けたコンソーシアム研究の展開」
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共同利用・共同研究拠点「ウイルス・幹細胞システム医生物学共同研究拠点」
世話人：京都大学医生物学研究所：ウイルス制御分野橋口隆生(Tel:075-751-4049)