日時：	4月12日（金）16:30～17:30
場所：	医生研３号館３階セミナー室（312）
演者：	眞貝　洋一　先生（理化学研究所・開拓本部）
演題：	Biology of histidine methylation

講演要旨

Enzymatic methylation occurs in diverse cellular molecules, including DNA, 

RNA, and proteins. Histidine (His) residues of cellular proteins have been reported 

to be methylated for more than five decades; however, the specific roles and 

biological functions of histidine methyltransferases (His MTases) remain largely 

unknown. My group has pioneered the use of an analogue of S-adenosylmethionine 

(the methyl donor for cellular methyltransferases) and click chemistry to identify 

the novel substrates of various protein methyltransferases and is now more focusing 

on protein histidine methylation.

　In my talk, I would like to present our analysis of His methyltransferases and discuss 

with the participants the currently emerging findings on the regulation of His 

methylation and its importance in biological functions.



世話人：幹細胞遺伝学分野　遊佐宏介