日時：	2025 February 14th, 14:00-15:00
場所：	Conference Room (Room 134) 1st floor, Bldg. No.1
演者：	Kotaro Fujii, Ph.D. Assistant Professor Center for NeuroGenetics Department of Molecular Genetics & Microbiology University of Florida
演題：	Controlling the fidelity of protein synthesis and its impact on disease

講演要旨

A key question in gene regulation is how information encoded in the genome is expressed with high fidelity
and precision to enable cells to adapt to their environment. However, gene regulation at the mRNA translation
level has been underestimated for a long time and this step has the highest error rate among gene expression
steps with an estimated 10-15% of nascent proteins containing errors. Such error-containing proteins are prone
to misfolding and aggregation. Therefore, fidelity of mRNA translation could contribute to proteostasis
imbalance, neurodegeneration, and aging. Despite its significance, the spatiotemporal dynamics and
regulatory mechanisms of translation fidelity remain poorly understood. In this presentation, I will introduce
our novel mouse model system that provides the landscape of translation fidelity and reveals unexpected
levels of spatiotemporal dynamics. I will further explore two novel molecular mechanisms that regulate
translation fidelity. 　20250214_ProfFujii

 

医生物学研究所　ナノ生物工学分野
新宅博⽂（shintaku[@]infront.kyoto‐u.ac.jp）