日時：	2024年3月14日（金）16：30～17：30
場所：	南部総合研究１号館１階共同セミナー室１ Shared Seminar Room 1, 1st Floor, Bldg. No. 1
演者：	Naoto Yoshinaga, Ph.D. SPDR, Biomacromolecule Research Team, RIKEN Center for Sustainable Resource Science Assistant Professor, Institute for Advanced Biosciences, Keio University
演題：	Design of an Artificial Peptide Inspired by Transmembrane Mitochondrial Protein for Escorting Exogenous DNA into the Mitochondria

講演要旨

Mitochondria are crucial for cellular function, but their own genome, mitochondrial DNA (mtDNA), often gets mutations, which lead to mitochondrial dysfunction and diseases. To recover the desperate condition by supplying genes, this study developed a peptide-based gene delivery carrier inspired by a mitochondrial transmembrane protein, mitoNEET. The nanoparticles direct the encapsulated genes to the mitochondria, enabling efficient uptake and expression. Delivery of exogenous mtDNA to mtDNA-depleted ρ0 cells restored multiple mitochondrial functions. This scalable approach holds promise for mitochondrial gene therapy and advanced genome-editing applications, offering a comprehensive breakthrough in treating mitochondrial dysfunction.

 

20250314_1st PR2 Seminar (Dr Naoto Yoshinaga)

Host: Koichiro Maki (maki[@]infront.kyoto-u.ac.jp)