日時：	2025年4⽉3⽇(木) 　10:30‐11:30
場所：	医⽣研1号館 1階セミナー室（119）室（Zoomでのハイブリッド開催）
演者：	Shintaro Yamada, PhD Chief researcher Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science
演題：	Mechanogenetics: toward an understanding of organ-specific gene regulation

講演要旨

Gene regulation has been primarily explained with signal transduction and transcription factor binding to the
genome. However, emerging evidence suggests that gene expression controls through mechanical “forces” such as
cleavage and structural changes of the genome, and physical pressure to the cell is essential for organ development
and functions. Moreover, its disruption can cause aging and diseases such as cancer. This seminar focuses on
mechanical regulation of the genome and, as an example, involvement of DNA cleavage and repair machinery in
gene expression in response to extracellular stimuli. We will discuss how such intracellular “forces” can be linked
to cellular mechano-microenvironments. Understanding types, degrees, and frequencies of “forces” as gene
regulatory elements brings a unique perspective on mechanisms in development and disease, and therapeutics.

 

20250403_12th nanobiofluids seminar（Shintaro Yamada, PhD）

 

Host: Hirofumi Shintaku, shintaku[@]infront.kyoto-u.ac.jp