日時：	2025年4月16日（水）15：00～16：30
場所：	医生物学研究所　２号館１階セミナー室（104室）
演者：	Tadashi Uemura Graduate School of Biostudies and Center for Living Systems Information Science (CeLiSIS), Kyoto University
演題：	Nutri-developmental biology: Impacts of nutrition histories in juvenile stages on growth, organogenesis, and lifespan.

講演要旨

Postembryonic development is characterized by massive and rapid growth of juveniles. This
developmental stage, in early life, is heavily influenced by the quality and quantity of
nutrients consumed by the juveniles. The impact of the nutritional environment in the early
life —referred to nutrition history— is not restricted to that stage, but that it also exerts longterm
health effects later in life, even to adult stages. However, unveiling its underlying
mechanisms of such far-reaching effects of the nutrition histories has been hampered by a
lack of appropriate experimental models. To address this challenge, we have developed a
novel interspecies assay using Drosophila melanogaster larvae fed with various mutants of
budding yeast. A larval diet comprised of yeast nat3 KO shortened the adult lifespan; and
remarkably, this diet diminished the function of histone acetyltransferase Gcn5 in larvae. We
have addressed whether the diminished Gcn5 function in larval stages is a cause of the
shorter lifespan in adults, investigated the larval cell type that contributes to the early death
of adults, and identified key nutrients in the nat3 KO yeast. We are also investigating genetic
programs that ensure the development of one of the tissues critical in our responses to diets,
the adipose tissue.　(Language: English)

0416_Theoretical Biology Seminar（Tadashi Uemura_CeLiSIS, Kyoto University）

contact:
Atsushi Mochizuki
Laboratory of Mathematical Biology,
Institute for Life and Medical Sciences, Kyoto University
Email: mochi[@]infront.kyoto-u.ac.jp
Tel: 075-751-4612