日時：	2019年11月6日 （水）15：00～16：00
場所：	京都大学 ウイルス再生研　2号館(旧ウイルス研本館） 1階セミナー室
演者：	Prof. Marcelo J. Kuroda, MD, PhD (VM: Anatomy, Physiology and Cell Biology, Center for Comparative Medicine Leader, Infectious Disease Unit, California National Primate Research Center, University of California, Davis, USA)
演題：	Understanding the role of macrophages in the pathogenesis of cardiovascular disease in HIV/AIDS using the nonhuman primate model

講演要旨

Cardiovascular disease is a major cause of morbidity in HIV-infected individuals despite undergoing effective cART and appears to be associated with macrophage activation and inflammation. Using nonhuman primate models that simulate human disease, we previously reported that distinct lung macrophage populations play different roles in the pathogenesis of pulmonary disease during SIV infection in rhesus macaques.  Specifically, short-lived macrophages were more readily destroyed by SIV and contributed to AIDS pathogenesis.  Long-lived macrophages on the other hand were not easily destroyed by virus and thus may contribute to establishing a long-term virus reservoir and promoting chronic inflammation. Recent studies are extending this work to characterize the roles of macrophages in heart and skeletal muscles affecting the cardiomyopathy observed in SIV/HIV infection.

 

1. Hasegawa, A., Liu, H., Ling, B., Borda, J.T., Alvarez, X., Sugimoto, C., Vinet-Oliphant, H., Kim, W.K., Williams, K.C., Ribeiro, R.M., Lackner, A.A., Veazey, R.S., Kuroda, M.J. (2009) The level of monocyte turnover predicts disease progression in the macaque model of AIDS. Blood 114, 2917-25.
2. Preferential destruction of interstitial macrophages over alveolar macrophages as a cause of pulmonary disease in SIV-infected rhesus macaques. Cai Y, Sugimoto C, Arainga M, Midkiff CC, Liu DX, Alvarez X, Lackner AA, Kim, W-K, Didier ES, Kuroda MJ. J Immunol. 2015;195(10):4884-91. doi: 10.4049/jimmunol.1501194. PubMed PMID: 26432896; PMCID: PMC4637238.
3. Merino KM, Allers C, Didier ES, Kuroda MJ. Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome. Front Immunol. 2017;8:1693. doi: 10.3389/fimmu.2017.01693. PubMed PMID: 29259605; PMCID: PMC5723290.
4. Petkov DI, Liu DX, Allers C, Didier PJ, Didier ES, Kuroda MJ. Characterization of heart macrophages in rhesus macaques as a model to study cardiovascular disease in humans. J Leukoc Biol. 2019. Epub 2019/07/10. doi: 10.1002/JLB.1A0119-017R. PubMed PMID: 31287581.
5. Takahashi N, Sugimoto C, Allers C, Alvarez X, Kim WK, Didier ES, Kuroda MJ. Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques. J Immunol. 2019;202(9):2682-9. doi: 10.4049/jimmunol.1801457. PubMed PMID: 30926643; PMCID: PMC6478513.

（言語：日本語　Language: Japanese）

 

 

主　催	京都大学ウイルス・再生医科学研究所
連絡先	ウイルス感染症モデル分野 明里　宏文 （TEL:075-751-4798）